Brain Diseases. Drug Discovery.

We study the molecular, cellular, and neural-network basis of human brain diseases to ultimately develop precision medicine therapeutics.

With a focus on neurodevelopmental disorders, epilepsy, and brain tumors, we develop innovative small molecule, nucleic acid, and cell therapeutic strategies to treat or even cure such devastating brain diseases.

Fundamental Science

Our lab is dedicated to advancing precision medicine for brain disorders using genome-edited human stem cells. We leverage cutting-edge technologies including single-cell RNA sequencing, CRISPR gene editing, human stem cells, and organoid cultures to ask the following questions: 1) Can the progression of neurodevelopmental disorders be halted or even reversed after disease onset? 2) Can a few mechanism-targeted drugs be utilized to treat a large number of brain diseases? 3) Can the neuroimune microenvironment be recapitulated in a culture dish?

Translational Science

With active collaborations among clinicians at the BCH Department of Neurosurgery and researchers in the F. M. Kirby Neurobiology Center, we are uniquely positioned to address unmet clinical needs through translational research and technology development. Our goal is to yield actionable scientific insights that help to fill the gap between basic science and the development of therapeutics for the clinical treatment of brain disorders. 

Join Us!

Are you passionate and devoted to the understanding of brain function and dysfunction at the deepest level? The Tang Lab at Boston Children’s Hospital is seeking highly motivated and talented postdoctoral fellows in the areas of molecular/cellular neuroscience, electrophysiology, or cancer biology. Join our team. 

We thank our funding sources for their trust and support