F.M. Kirby Neurobiology Center

The F.M. Kirby Neurobiology Center is fully committed to recruiting and supporting the full spectrum of our diverse population and ensuring that everybody has a place in our research community.

Kirby People

Kirby Director

Clifford Woolf, MB, BCh, PhD

Director, F.M. Kirby Neurobiology Center, Boston Children’s Hospital

Professor of Neurobiology and Neurology, Harvard Medical School

Blackfan Diamond Chair in Neuroscience Research, Boston Children’s Hospital

Adaptive and Maladaptive Plasticity in Sensory and Motor Systems

The Woolf lab studies how different forms of neuronal plasticity contribute both to adaptive and maladaptive changes in the mammalian nervous system, particularly in relation to pain, regeneration and neurodegenerative diseases. We have established functional and comparative genomic strategies using expression profiling, bioinformatics and gain- and loss-of-function approaches, to screen for novel genes that contribute to neuronal plasticity and disease phenotypes. Our group works closely with many academic groups, including the Harvard Stem Cell Institute, the Broad Institute and the pharmaceutical industry.

Kirby Faculty

Chinfei Chen, MD, PhD

Professor of Neurology and Neurobiology, Harvard Medical School
Synapse & Circuit Plasticity in the Brain

Our lab seeks to understand the mechanisms that underlie synaptic plasticity in the young and mature mammalian central nervous system. Our studies have focused on the thalamus, a brain region that regulates consciousness, sleep, alertness and the integration of sensory information. One area of deep interest is the establishment and optimization of thalamic circuits during development in this region. We have found that thalamic circuits exhibit robust changes in network connectivity over development that shapes the nature of the information transmitted. Our research may have significant implications for our understanding of neurodevelopmental disorders such as autism spectrum disorders, intellectual disabilities, epilepsy and neuropsychiatric disorders.

Full Profile > | Chen Lab >

Michael Crickmore, PhD

Associate Professor of Neurology, Harvard Medical School
Studying Motivation in Small Brains

The Crickmore lab uses mating drive in male fruit flies to study how motivations are produced by the brain. The lab applies neurogenetic and imaging tools to understand the molecular and circuit mechanisms by which dopamine output is calibrated to internal states and is used to motivate appropriate behavior. Dopamine dysregulation is implicated in ADHD, depression, schizophrenia, and addiction so we have reason to be optimistic that this work will fuel new hypotheses for researchers studying these disorders.

Full Profile > | Crickmore Lab >

Michael Do, PhD

Associate Professor of Neurology, Harvard Medical School
Neural Signaling for Perception and Physiological Regulation

We ask how light drives functions that are as diverse as visual perception, sleep regulation, hormonal control, and setting of the internal body clock.  Our research spans organizational levels and time scales, from molecules to circuits and from milliseconds to hours. It centers on electrophysiological and optical techniques that are applied in vitro and in vivo.

Full Profile > | Do Lab >

Darius Ebrahimi-Fakhari, MD, PhD

Director, Movement Disorders Program
Attending, Neurologist, Boston Children’s Hospital
Assistant Professor, Harvard Medical School
Translational research in childhood-onset movement disorders

Our team is committed to unraveling the molecular underpinnings of genetic childhood-onset movement disorders. By doing so, we strive to pave the way for the development of novel therapies, encompassing both small molecules and gene-based approaches. Our ultimate goal is to improve the lives of children affected by neurogenetic disorders through the development of innovative and effective therapies.

 Full Profile > | Ebrahimi-Fakhari Lab >

Elizabeth Engle, MD

Investigator, Howard Hughes Medical Institute

Professor of Neurology and Ophthalmology, Harvard Medical School 
Cranial motor neuron and axon development

We have found that the developmental anatomy of human cranial motor neurons, which originate in the brainstem and send axons to innervate the cranial muscles, is stereotypical, tractable, and conserved in model organisms, thus providing a beautiful paradigm for more complex neurodevelopmental processes. We study aberrant cranial motor neuron development by identifying human congenital disorders of eye and face movement, defining their genetic etiologies, and uncovering their molecular pathways and disease mechanisms. We also study normal cranial motor neuron development in mouse and zebrafish.

Full Profile > | Engle Lab >

Michela Fagiolini, PhD

Associate Professor of Neurology, Harvard Medical School
Experience-Dependent Neuronal Development

Our work focuses in understanding how the brain develops and adapts to the external environment in health and disorders. We study the mechanisms underlying fundamental processes and how they may be altered in autism related disorders, Rett Syndrome and CDKL5 disorder in particular. We aim to identify new target treatments by combining molecular techniques with electrophysiological, two-photon imaging and behavioral analysis of systems level phenomena in vivo and parallel with translational studies in patients.

Full Profile >

Jordan Farrell, PhD

Assistant Professor of Neurology, Harvard Medical School
Targeting hijacked circuit mechanisms in brain disorders

We seek to understand the mechanisms by which heterogenous cell types orchestrate synchronous network patterns for brain computations as fundamental as memory, which may be key to understanding the origins of pathological hypersynchrony in epilepsy. Using cutting-edge in vivo approaches to home in on these mechanisms with precision, our goal is to restore circuit function with minimal side effects. As a step towards translation, we are developing new tools to uncover mechanisms of ultrasound neuromodulation and use parameter-optimized stimulation patterns to achieve cell type-specificity, but without the need for surgery or genetic manipulations.

Full Profile > | Farrell Lab >

Brielle Ferguson, PhD

Assistant Professor of Genetics and Neurology, Harvard Medical School
Identifying mechanisms of attention disruption in neurodevelopmental disorders

The Ferguson lab will work to discover and characterize biomarkers of successful and dysfunctional cognitive function by monitoring and manipulating relevant circuits using Calcium imaging, optogenetics, pharmacogenetics, various slice and in vivo electrophysiology approaches, and behavior. We’ll examine these biomarkers in mice with mutations linked to autism-spectrum disorders, schizophrenia, and epilepsy to highlight shared signatures of cognitive dysfunction. We are particularly interested in the role of interneurons in regulating neuronal ensembles critical for completing various cognitive tasks. A long-term goal is to identify therapeutic targets for treating patient populations across disease contexts with treatment-resistant cognitive impairments.

Full Profile > | Ferguson Lab (Website Coming Soon) >

Gwenaelle Géléoc, PhD

Associate Professor of Otolaryngology, Harvard Medical School
Functional Development of Sensory Hair Cells in the Inner Ear

The primary goal of our research is to characterize the functional and molecular development of inner ear hair cells. We are applying our knowledge and expertise to study gene mutations that cause Usher Syndrome, the most common form of combined deafness and blindness.

Full Profile > | Holt/Géléoc Lab >

Xi He, PhD

Professor of Neurology, Harvard Medical School
Wnt Signaling in Development and Adulthood

My lab seeks to understand the molecular basis of cell-to-cell communication, and how this communication regulates embryonic and neural development in vertebrates. We are also interested in learning how defective regulation of cell communication causes human cancers and diseases. We aim to identify molecular components of Wnt signaling pathways and the mechanisms by which Wnt pathways are activated and governed during embryonic development and human tumorigenesis.

Full Profile > | He Lab >

Zhigang He, PhD, BM

Professor of Neurology, Harvard Medical School 
Axon Regeneration and Functional Restoration In the Adult CNS

Our recent studies have led to the development of novel and effective genetic methods (deletion of PTEN and/or SOCS3) for re-activating neuronal regenerative capacity and thereby allowing for robust regenerative growth after injury, representing a major achievement in the first step of neural repair. Our ongoing studies are focusing on three questions: (1) How to further increase axon regeneration after injury? (2) How to activate spared yet dormant connections in incomplete injury models? (3) What are the physiological functions of different brain-derived descending projections to the spinal cord?

Full Profile > | He Lab >

Takao Hensch, PhD

Professor of Neurology, Harvard Medical School

Professor of Molecular and Cellular Biology, Harvard University
How Experience Shapes Brain Development

Our lab examines how early life experience shapes brain function, by examining the cellular and molecular factors controlling ‘critical periods’ or ‘sensitive periods’ in brain development. Integrating molecular, cellular and systems neuroscience, we have revealed that these periods are themselves plastic and reversible. Specific, inhibitory (GABA) circuits determine their onset timing, and “brake”-like factors ultimately consolidate this potent rewiring process. Translational research at Boston Children’s Hospital inspired by our work targets recovery from neurodevelopmental disorders, such as amblyopia, epilepsy and autism spectrum disorders.

Full Profile > | Hensch Lab >

Jeffrey Holt, PhD

Professor of Otolaryngology and Neurology, Harvard Medical School
Function, Dysfunction and Restoration in the Auditory System

We have an active research group focused on the function, dysfunction and restoration of the auditory system. Our goal is to understand how stimuli from the external world, such as sound, gravity and head movements are converted into electrical signals, how the information is encoded and how it is transmitted to the brain. We want to understand why genetic mutations cause hearing loss and vestibular dysfunction. We are using this information to design novel therapeutic innervations to treat deafness and balance disorders.

Full Profile > | Holt/Geleoc Lab >

Karl Koehler, PhD

Associate Professor of Otolaryngology-Head and Neck Surgery, Harvard Medical School 
Development and regeneration of peripheral sensory systems

Our lab aims to understand how complex sensory systems form and begin functioning in the developing human body. Our goal is to use this knowledge to design new cell- or gene-based therapies for sensory disorders. Recently, we established some of the first human organ-in-a-dish models of the inner ear and skin, which accurately mimic development of specialized epithelia cells, sensory nerves, and hair follicles, among other tissue types. We use a variety of techniques to investigate these models, including gene editing, single-cell genomics, and functional imaging.

Full Profile > | Koehler Lab >

Gabriel Kreiman, PhD

Professor of Ophthalmology, Harvard Medical School 
Neurobiological mechanisms underlying biological and artificial intelligence

Our lab focuses on elucidating the neural circuits and computational mechanisms underlying visual intelligence. The lab combines invasive neurophysiological recordings in the human brain, behavioral experiments and computational modeling to understand the neuronal circuits, algorithms and computations performed by the visual system. Examples of recent investigations include deciphering the algorithms to make inferences from partial information (pattern completion), transformation-invariant mechanism for visual recognition

Full Profile > | Kreiman Lab >

Wei-Chung Allen Lee, PhD

Associate Professor of Neurology, Harvard Medical School
Unraveling the Anatomy of Thought and Action.

Our work is aimed at understanding the organizational principles that underlie information processing in neural circuits through the application of ‘functional connectomics’ to discover the relationship between circuit structure and function in the Drosophila and rodent brain.

Full profile > | Lee Lab >

Jonathan Lipton, MD, PhD

Assistant Professor of Neurology, Harvard Medical School
Circadian Rhythms & Disease of the Brain

Our lab seeks to understand the fundamental relationships between the circadian clock and diseases of the developing brain. We have demonstrated that the circadian clock is disrupted in neurodevelopmental disorders, reflecting the central connection between them and the circadian clock. We seek to define the mechanisms by which circadian information is reorganized or disorganized in animal models of neurological disease and in patient-derived samples.

Full Profile > | Lipton Lab >

Annapurna Poduri, MD, MPH

Professor of Neurology, Harvard Medical School

Translational Studies in Epilepsy Genetics

Our lab, working with the Epilepsy Genetics Program, performs translational research focused on genetic epilepsies from both a human genetics and a functional modeling perspective. We also partner with the Rosamund Stone Zander Translational Neuroscience Center, Harvard Stem Cell Institute, and Woolf Lab to conduct studies of neurons derived from patient cell lines.

Poduri Lab >

Scott Pomeroy, MD, PhD

Bronson Crothers Professor of Neurology, Harvard Medical School 
Growth Factor Regulation of Neural Development and Oncogenesis

My lab is focused on discovering the normal cells in the developing brain from which medulloblastomas arise, and the molecular mechanisms giving rise to this cancer. We aim to develop more effective and less toxic targeted therapies.

Full Profile > | Brain Tumor Center>

Alexander Rotenberg, MD, PhD

Director, Epilepsy Monitoring Unit, and Director, Neuromodulation Program, Boston Children’s Hospital

Professor of Neurology, Harvard Medical School
Noninvasive brain stimulation in Epilepsy and Brain Injury

We work to identify biological targets which can stop or prevent seizures if manipulated by either brain stimulation or by novel drugs. We are also studying the molecular changes associated with TBI in rats, as well as testing novel approaches to prevent brain injury and seizures after TBI. In parallel, we have ongoing clinical projects aimed to further develop techniques for noninvasive brain stimulation, particularly TMS and tDCS, as diagnostic and therapeutic tools in child neurology.

Full Profile >

Mustafa Sahin, MD, PhD

Neurologist-in-Chief, Chair, Department of Neurology, Boston Children’s Hospital

Director, Rosamund Stone Zander Translational Neuroscience Center, and Director, Translational Research Program, Boston Children’s Hospital

Rosamund Stone Zander Professor of Neurology, Harvard Medical School
Cellular Mechanisms Underlying Childhood Neurogenetic Disorders

Our research is directed at understanding the cellular mechanisms underlying childhood neurogenetic disorders. We have predominantly focused on Tuberous Sclerosis Complex (TSC), a genetic disorder that presents often with epilepsy and autism. We are also involved in clinical and pre-clinical work through the Rosamund Stone Zander Translational Neuroscience Center at Boston Children’s Hospital for patients with PTEN Hamartoma Syndrome, Rett Syndrome, Tuberous Sclerosis Complex and Phelan-McDermid Syndrome.

Full Profile > | Sahin Lab >

Rosamund Stone Zander Translational Research Program >

Thomas Schwarz, PhD

Professor of Neurology and Neurobiology, Harvard Medical School
The Cell Biology of Neurons

Our lab is focused on the cell biology of the neuron and seeks to understand how nerve cells work and keep their distant parts well-supplied and healthy. We do so with the expectation that understanding how the cell functions can give us insight into the pathology of neurological disorders when those functions fail. We work with Drosophila melanogaster, mice, rats, and human cell lines as the scientific question demands. We approach each question through a combination of genetics, biochemistry, electrophysiology, cell biology, pharmacology, and imaging.

Full Profile > | Schwarz Lab >

Judith A. J. Steen, PhD

Associate Professor of Neurology, Harvard Medical School
Proteogenomics of Regeneration and Degeneration in the Nervous System

Our lab applies systems biology approaches to understand neuro-regeneration and neurodegeneration. We develop novel qualitative and quantitative workflows at the interface of proteomics and transcriptomics to collect large data sets that are then mined using both available software and in house developed tools. The goal of this research is to use molecular information provided by our quantitative proteomics measurements to ameliorate neurodegeneration and promote regeneration. We are currently applying our analytical and computational workflows to Alzheimer’s Disease, Frontotemporal Dementia, Spinal Muscular Atrophy and Parkinson’s Disease.

Full Profile > | Steen Lab >

Beth Stevens, PhD

Investigator, Howard Hughes Medical Institute

Associate Professor of Neurology, Harvard Medical School
Neuron-Glia Interactions in Development and Disease

A major goal of our lab is to elucidate the cellular and molecular mechanisms underlying activity-dependent synapse elimination during health and disease, with emphasis on the role of microglia and immune molecules in this process. Using the visual system as our primary model system, we employ a combination of live imaging, molecular, biochemical and neuroanatomical approaches. Current research questions include: How are CNS synapses selectively targeted for elimination? Is complement-dependent synapse elimination an activity-dependent process? What is the role of astrocytes and microglia in synapse development and elimination?

Full Profile > | Stevens Lab >

Xin Tang, PhD

Assistant Professor of Neurosurgery, Harvard Medical School
Understanding brain function and dysfunction from model to mechanism to medicine

Our lab seeks to understand the molecular and cellular basis of human brain disorders in order to ultimately develop mechanism-guided therapeutics that relieve disease symptoms. With a research focus on neurodevelopmental disorders, epilepsy, and brain cancer, we create physiologically-relevant models to elucidate disease mechanisms and develop drug and gene discovery platforms to screen for potential therapeutics that can regulate the expression levels of disease risk genes. In order to develop novel precision medicine, we employ a multidisciplinary approach that leverages technologies spanning genome engineering, human stem cell differentiation, organoid culture, single cell-omics, bioinformatics, biochemistry, electrophysiology, and high-throughput gene/drug screening.

Full Profile > | Tang Lab >

Hisashi Umemori, MD, PhD

Professor of Neurology, Harvard Medical School
Synaptic Network Development

Our lab is interested in the molecules and mechanisms by which specific and functional synaptic connections are established in the brain, and is applying the findings to the prevention and treatment of neurological/psychiatric disorders. We use molecular & cellular biological, mouse genetics, biochemical, histological, physiological, behavioral, and imaging techniques. Through our work, we aim to understand the principle of mammalian brain wiring and how the functional brain is built. Our discoveries will be applied to the prevention or treatment of neurological and psychiatric disorders associated with abnormal synapse formation, such as autism, schizophrenia, and epilepsy.

Full Profile > | Umemori Lab >

Affiliated Faculty

Mark Andermann, PhD

Professor of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center
How Motivation Shapes Perception

Our lab studies how the needs of the body determine which sensory cues are attended to, learned, and remembered. We investigate how natural and experimentally induced states of hunger modulate neural representations of food cues—and the resulting consequences for obesity, binge eating and other eating disorders. Using two-photon calcium imaging and multi-electrode recording in behaving mice, we are investigating the mechanisms by which genetically, anatomically and chemically defined classes of cortical neurons facilitate cue-induced feeding in a hunger-dependent manner.

Full Profile > | Andermann Lab >

Mandana Arbab, PhD

Assistant Professor of Neurology, Harvard Medical School
Translational genome editing for neurodegenerative diseases

Many neurodegenerative diseases are caused by known genetic mutations, but how these genetic abnormalities cause pathology is often poorly understood. Genome editing may provide a lasting treatment for many genetic disorders by correcting disease mutations or making compensatory changes to the genome. We use genome editing tools to investigate cellular mechanisms of neurodegeneration to study the impact of genetic mutations in cell and animal models of neurological diseases, and to develop genome editing therapeutic strategies that may one day treat neurological diseases in patients.

Full Profile > | Arbab Lab >

Maya Chopra, MBBS, FRACP

Director, Translational Genomic Medicine Core, Rosamund Stone Zander Translational Neuroscience Center, Boston Children’s Hospital

Assistant Professor of Neurology, Harvard Medical School 
Discovery and delineation of new and emerging rare genetic syndromes with a neurodevelopmental presentation

Dr Chopra’s research interest is in rare syndromic causes of neurodevelopmental presentations. She is interested in the systematic evaluation of such disorders for suitability for multidisciplinary clinics, clinical trial readiness and gene-based therapies. She collaborates closely with local and external investigators in research efforts to understand the mechanisms underpinning neurodevelopmental syndromes, and how they can translate into treatment options.

Full Profile >

Eric Gaier, MD, PhD

Assistant Professor of Ophthalmology, Havard Medical School
Neural mechanisms of interocular suppression and recovery from amblyopia

Amblyopia (“lazy eye”) is a neurodevelopmental disorder accounting for visual impairment among a significant number of children and adults. Current standards in therapy target occlusion (patching) or penalization (cycloplegia) of the better-seeing eye, but these therapies carry major limitations in efficacy and adherence. Our lab conducts basic science research related to amblyopia using a mouse model. By elucidating and leveraging the mechanisms that underlie visual, experience-dependent synaptic changes in the brain, our research efforts are aimed at advancing our understanding of and developing new strategies to treat amblyopia.

Full Profile >

David Glahn, PhD

Director, Tommy Fuss Center for Neuropsychiatric Disease Research

Director, Program for Behavioral Science, Department of Psychiatry, Boston Children’s Hospital
How do behavioral disorders evolve over time?

What are the mechanisms that cause developmental pathways to diverge, leading some children and adolescents to pathological disorders and others to healthy outcomes? Through a multifaceted program that integrates psychiatry, neuroscience, genetics, stem cell science, bioinformatics, and brain imaging, our aim is to unlock the genetics and biology of psychiatric disease, with a focus on early detection, prevention, and intervention to protect and treat the most vulnerable community of children and young adults.

Full Profile > | Tommy Fuss Center >

Maxwell Heiman, PhD

Associate Professor of Genetics, Harvard Medical School 
Morphogenesis of neurons and glia

The goal of our lab is to understand how cells get their shapes and assemble into organs. Defects in this process lead to structural birth defects. We are using forward genetic approaches in C. elegans to identify the genes that give individual cells their characteristic shapes and that specify defined cell-cell contacts.

Full Profile > | Heiman Lab >

Jed Hubbs, PhD

Director, Medicinal Chemistry, Rosamund Stone Zander Translational Neuroscience Center, Boston Children’s Hospital

Assistant Professor of Neurology, Harvard Medical School
Discovering new treatments for neurological disorders across the lifespan

We seek to deliver new small molecule therapeutics to patients with neurodevelopmental and neurodegenerative disorders. Advances in disease genomics, patient-derived neuron cell culture, and gene editing are opening new avenues to screen drugs for their ability to correct a disease state. Once a molecule has been identified, we can use it to launch a drug discovery program and elucidate new therapeutic mechanisms.

Full Profile >

Brian Kalish, MD

Attending Neonatologist, Boston Children’s Hospital

Assistant Professor of Pediatrics, Harvard Medical School
Mechanisms of Fetal and Neonatal Brain Injury

Our lab focuses on the protection and rehabilitation of the newborn brain. We seek to understand how pregnancy and early life experience shape neurodevelopment and brain plasticity. Through cutting-edge molecular neuroscience and genomics, we investigate fundamental questions at the intersection of neurobiology and reproductive health. In particular, we are interested in maternal-fetal neuroimmune interactions and the relationship with later life risk of neurodevelopmental disorders. We are also interested in how the maternal brain adapts during pregnancy, and how this plasticity is related to both maternal behavior and peripartum psychiatric disease.

Kalish Lab

Dong (a.k.a. Don) Kong, PhD

Member of the Faculty in Pediatrics, Harvard Medical School
Neural Circuitry and Synaptic Plasticity of Neuron-Metabolism

The long-term interest of our laboratory is to bridge molecular, cellular, and system approaches to understand the neuronal modulation and circuitry involved in the pathogenesis of neurological diseases. Specifically, we are leveraging and combining a cornucopia of cutting-edge technologies, from genetically engineered mouse models, recombinant viral vectors and viral tracing system, optogenetic and pharmacogenetic approaches, patch-clamp electrophysiology, calcium imaging, to 2-photon laser scanning microscopy and 2-photon laser uncaging methods (2PLSM/2PLU), to explore the molecular and circuit mechanisms underlying feeding related behaviors and metabolic homeostasis.

Full Profile |

Maria K. Lehtinen, PhD

Hannah C. Kinney, MD, Professor of Pediatric Pathology Research, Boston Children’s Hospital

Professor of Pathology, Harvard Medical School
Signaling Mechanisms That Regulate Neuronal Survival and Death

We study cerebrospinal fluid-based signaling during brain development and disease and the fundamental mechanisms that regulate the development and maintenance of the mammalian brain.

Full Profile > | Lehtinen Lab >

Emily Osterweil, PhD

Associate Professor of Neurology, Harvard Medical School

Synaptic protein homeostasis

Our research seeks to understand how protein synthesis at the synapse is used to facilitate experience-dependent changes in brain function. Advances in technology have led to an increasingly complex picture of the RNA landscape of the neuron. Specific mechanisms of splicing, transport and translation have been identified that allow activity driven changes to persist at synapses. We are using new tools in RNA sequencing, proteomics and imaging to understand how specific neuron populations encode information through changes in the RNA and protein environment. Our goal is to gain a better understanding of experience dependent learning, and discover how dysregulation of translation causes pathology in neurodevelopmental disorders such as Fragile X Syndrome (FXS).

Full Profile > | Osterweil Lab >

Meenakshi Rao, MD, PhD

Attending Physician, Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital

Assistant Professor of Pediatrics, Harvard Medical School 
Enteric Neurobiology: The “Brain” in the Gut in Health and Disease

Our lab is working to understand how the neurons and glial cells of the enteric nervous system (ENS) detect and use information about nutrients, microbes, and mechanical stimuli to regulate gastrointestinal, metabolic and immune responses. We use mouse genetic models, in vivo and in vitro assays to investigate ENS circuits and their role in the gut-brain axis. The overall goal of our work is to determine how ENS dysfunction contributes to digestive and neurological disorders.

Full Profile > | Rao Lab >

Marcos Simoes-Costa

Eliot Shearer, MD, PhD

Assistant Professor of Otolaryngology Head and Neck Surgery, Harvard Medical School

Hearing Genomics: from Bench to Bedside

Our lab studies the genomics of hearing loss in children. We work to improve diagnostics using new DNA sequencing techniques. We use mouse models to better understand the molecular physiology of hearing loss. We work closely with the Koehler lab to develop inner ear organoids from patients with hearing loss and with the Holt/Géléoc lab to speed the development of gene therapies.

Full Profile > | Lab Website >

Marcos Simoes-Costa

Marcos Simoes-Costas, PhD

Associate Professor of Systems Biology, Harvard Medical School

Genome regulation in embryonic development

In the Simoes-Costa Lab, we study how cellular diversity arises during vertebrate embryonic development. We employ systems-level approaches to decode the molecular programs that drive changes in cell identity. Our research group is particularly interested in how gene regulatory networks operate in space to give rise to complex arrangement of cells.

Our model of choice is the neural crest, a stem cell population that plays a crucial role in the genesis of the vertebrate body plan. Neural crest cells emerge from the central nervous system to give rise to intricate structures like the craniofacial skeleton and the peripheral ganglia. They have served as an essential developmental model system due to their motility and ability to form various cell types. We approach the neural crest as a system for integrative biology, surveying how multiple layers of regulation work together to control cell identity and behavior.

Full Profile > | Simoes-Costa Lab >

Hanno Steen, PhD

Director of the Proteomics Center, Boston Children’s Hospital

Professor of Pathology, Harvard Medical School
Proteomics and Brain Disorders

Dr. Steen’s lab is working on novel methods for identifying and quantifying various protein modifications that are involved in pediatric diseases in order to provide new insights into the underlying biological processes, a prerequisite for a rational approach to prevent and/or cure these diseases.

Full Profile > | Steen Lab >

Proteomics Center >

Christopher A. Walsh, MD, PhD

Chief, Division of Genetics and Genomics, Boston Children’s Hospital

Investigator, Howard Hughes Medical Institute

Bullard Professor of Pediatrics and Neurology, Harvard Medical School
Developmental Disorders of the Brain

Our lab is interested in identifying mutations in the mechanisms that regulate the normal development and function of the human cerebral cortex. Such mutations cause crippling consequences such as epilepsy, autism, and mental retardation or other learning disorders. Recent interests of the lab include identifying somatic mutations in the human brain as a cause of some forms of autism and epilepsy. In addition, we are using the human genetics of neurological disease to identify those portions of the genome that are most critical for the evolution of the Human Brain in the recently formed Allen Discovery Center for Human Brain Evolution.

Full Profile > | Walsh Lab >

Mary C. Whitman, MD, PhD

Assistant Professor of Ophthalmology, Boston Children’s Hospital

Assistant Professor of Ophthalmology, Harvard Medical School

Molecular Mechanisms of Oculomotor Development and Genetics of Strabismus

We are investigating the development of the nerves and muscles which control eye movements, in both normal development and in eye movement disorders, including nystagmus and strabismus. We are also searching for genetic causes of strabismus and exploring how genetic changes associated with strabismus alter development of the oculomotor system.

Full Profile > | Whitman Lab >

Timothy Yu, MD, PhD

Attending Physician, Division of Genetics and Genomics, Boston Children’s Hospital

Associate Professor in Pediatrics, Harvard Medical School
Bringing Genetic Tools to the Bedside

Our lab conducts genome-wide and world-wide searches to find the genes that are responsible for autism spectrum disorders (ASDs) and other neurodevelopmental conditions. We are passionate about finding ways to bring genomic tools to the bedside to help care for patients with genetic disorders. These projects range from the deployment of genome sequencing in the neonatal intensive care unit to the design and delivery of genome-guided therapeutics for sick children.

Full Profile > | Yu Lab >

Kirby Administration

Amy Weinberg

Senior Administrative Director, Research Programs

Amy is responsible for the overall administration of research in Neurobiology, Neurology, and Otolaryngology. She handles space allocations, legal agreements, basic and clinical research administration, promotions and merit increases, employee relations issues, sets policies and procedures, and manages the research administrative team within the three areas listed above.

Email Amy Weinberg >

Karen Caballero

Administrative Manager

Karen is responsible for onboarding all employees and associated personnel, from posting a job to securing a visa to getting cleared to begin work to processing BCH and Harvard appointments. She manages access to the server (OAR forms), website content updates, and marketing initiatives. She oversees educational and other events put on in the Kirby Center, and maintains our distribution lists.

Email Karen Caballero >

Padam Gharti

Research Administrative Manager

Padam manages pre- and post-award activities for faculty and fellows on the 13th and 14th floors of the CLS building, as well as for faculty conducting clinical research for the Department of Neurology. Padam manages our filemaker database, manages billing for our clinical trials, and supervises Kathy Rodrigues, Robin Scott and Dipendra Subedi.

Email Padam Gharti >

Bronwen Beaudoin

Program Manager II, Stevens Lab

Bronwen Beaudoin leads the operational and administrative functions for the Stevens Lab including oversight and management of research grants and fellowship applications, legal agreements, compliance, letters of support and annual reporting within the lab. She collaborates with cross-institutional teams and participates in the creation and execution of strategic planning.

Email Bronwen Beaudoin >

Jordan Bessette, PhD

Program Coordinator II

Jordan provides administrative support to Dr. Tom Schwarz and the T32 Fellowship program. He also coordinates EDI efforts for the Kirby Center.

Email Jordan Bessette >

Marie Boyle

Research Administrator

Marie provides research administrative support to Dr. Mustafa Sahin and his team, as well as to the Rosamund Stone Zander Translational Neuroscience Center. She also handles billing for the ADSF and Human Neuron Cores and populates effort reports for staff in her assigned labs.

Email Marie Boyle >

Tammy Chu

Administrative Coordinator, Engle Lab
Tammy is responsible for mandatory reporting (e.g. departmental / institutional reports and website updates, institutional grants, and sponsor progress reports), staffing (e.g. recruitment, on/off boarding, and visas), and MTA/contract execution for the Engle lab. In addition, she assists with grant applications and letters of support.

Email Tammy Chu >

SJ Cunningham

Executive Assistant to Kirby Center Director

SJ provides executive administrative support to Dr. Clifford Woolf and his lab, including pre-award grant support. SJ also serves as a member of the research administration team and is responsible for scheduling the faculty lunch series, planning and executing Kirby-wide events, assisting other faculty with grant submissions, managing the departmental End Note library, and aiding Kirby fellows with their faculty job searches along with Dr. Mike Do.

Email SJ Cunningham >

Liza Curtis

Sr. Administrative Associate, Stevens Lab
Liza Curtis provides administrative support to Dr. Beth Stevens.  She is responsible for submitting expense reimbursements, managing travel, organizing weekly lab meetings at CLS and providing day to day administrative support to the Stevens Lab.

Email Liza Curtis >

CJ Johnson

Executive Assistant to Director of the RSZ-TNC

CJ is the executive assistant to Dr. Mustafa Sahin and his lab, as well as providing administrative assistance to the Rosamund Stone Zander Translational Neuroscience Center and arranging the RSZ TNC Monthly Seminars.

Email CJ Johnson >

Cai Mathieu

Administrative Associate III

Cai provides administrative support to the Ferguson Lab and Black In Neuro. Her role with the Ferguson Lab involves schedule support, purchasing, reimbursements, recruitment. With Black In Neuro, she works across teams to help facilitate efficient operation within the organization and support ongoing programming.

Email Cai Mathieu >

Kathy Rodrigues

Senior Research Administrator

In addition to providing both pre- and post-award grant support to Drs. Judith Steen and Ann Poduri, Kathy assists fellows and some faculty on CLS 13 and 14 with their grant submissions. She also provides post-award support for faculty in the Department of Neurology.

Email Kathy Rodrigues >

Katie Rogers

Program Coordinator II

Katie helps in the planning and execution of the Neurobiology Seminar Series and Lab Results Talks for the Kirby Center. She helps with general administrative tasks, including purchasing and reimbursements, for the Kirby. She does the communications updates both internally and externally via social media, website updates, and the quarterly Kirby newsletter.

Email Katie Rogers >

Robin Scott

Research Administrator

Robin manages pre- and post-award activities for faculty and fellows conducting clinical research for the Department of Neurology.

Email Robin Scott >

Sable Smith

Research Administrator

Sable provides pre- and post- award grant support for the Rosamund Stone Zander Translational Neuroscience Center and Otolaryngology, and assists some Neurobiology investigators as well.

Email Sable Smith >

Dipendra Subedi

Financial Assistant

Dipendra handles Accounts Payable for our labs including submission of reimbursements for faculty, payment of invoices, and follow-up on unpaid invoices. Dipendra processes core facility billing for our Imaging, Neurobehavioral, Gene Manipulation, and Viral Cores. He ensures vendors are set up in PeopleSoft and orders supplies for our core facilities and clinical research labs outside of CLS. Dipendra handles enrollment-based billing for Neurology.

Email Dipendra Subedi >

Core Staff

Lee Barrett, PhD, ARCS

Assistant Director, Assay Development & Screening Facility

 

Mantu Bhaumik, PhD

Assistant Director, Mouse Gene Manipulation Core

 

Elizabeth Buttermore, PhD

Assistant Director for Phenotypic Assay Development, Human Neuron Core

Cidi Chen, PhD

Assistant Director, Human Neuron Core

 

Yiming Zhang

Cheng-Hao Chien, PhD

Multi-photon Manager, Cellular Imaging Core

 

Yiming Zhang

Harry Cramer, PhD

Assistant Director, Cellular Imaging Core

 

Mustafa Hameed, MD

Assistant Director, Experimental Neurophysiology Core

 

Nate Hodgson, PhD

Assistant Director, Neurodevelopmental Behavioral Core

 

Nina Makhortova, PhD

Assistant Director, Phenotyping Services

 

Dosh Whye, MA

Assistant Director, Human Neuron Core

 

Yiming Zhang

Yiming Zhang, PhD

Assistant Director, Viral Core

 

Credits: Most of these faculty head shots were taken by photographer Anna Olivella or Celia Muto, and used with permission from the  Harvard Brain Science Initiative.