2023 Publications
Nature
A transcriptomic taxonomy of mouse brain-wide spinal projecting neurons
Winter C.C, Jacobi A, Su J, Chung L, van Velthoven C, Yao Z, Lee C, Zhang Z, Yu S, Gao K, Duque Salazar G, Kegeles E, Zhang Y, Tomihiro M, Zhang Y, Yang Z, Zhu J, Tang J, Song X, Donahue R, Wang Q, McMillen D, Kunst M, Wang N, Smith K, Romero G, Frank M,Krol A, Kawaguchi R, Geschwind D, Feng G, Goodrich L, Liu Y, Tasic B, Zeng H, He Z. Nature 624, 403–414 (2023). https://doi.org/10.1038/s41586-023-06817-8
This study is part of part of a collection of papers for the Brain Initiative Cell Census Network 2.0(BICCN): The first complete cell census and atlas of a mammalian brain
See the immersive collection of studies here:
https://www.nature.com/immersive/d42859-023-00069-2/index.html
Elife
Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons
Pederick DT, Perry-Hauser NA, Meng H, He Z, Javitch JA, Luo L. Elife. 2023 Mar 20;12:e83529. doi: 10.7554/eLife.83529.
Nature Immunology
Temporal single-cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury
Benhar I, Ding J, Yan W, Whitney IE, Jacobi A, Sud M, Burgin G, Shekhar K, Tran NM, Wang C, He Z, Sanes JR, Regev A.
Nat Immunol. 2023 Apr;24(4):700-713. doi: 10.1038/s41590-023-01437-w. Epub 2023 Feb 20.
PNAS
Transcriptomic Analysis of the Ocular Posterior Segment Completes a Cell Atlas of the Human Eye
Monavarfeshani A, Yan W, Pappas C, Odenigbo KA, He Z, Segrè AV, van Zyl T, Hageman GS, Sanes JR.
Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2306153120. doi: 10.1073/pnas.2306153120. Epub 2023 Aug 11. PMID: 37566633
bioRxiv
The Secondary Somatosensory Cortex Gates Mechanical and Thermal Sensitivity
Taub DG, Jiang Q, Pietrafesa F, Su J, Greene C, Blanchard MR, Jain A, El-Rifai M, Callen A, Yager K, Chung C, He Z, Chen C, Woolf CJ.
bioRxiv. 2023 May 22:2023.05.19.541449. doi: 10.1101/2023.05.19.541449. Preprint.
2022 Publications
Science Advances
Somatosensory cortical signature of facial nociception and vibrotactile touch-induced analgesia
Lu J, Chen B, Levy M, Xu P, Han BX, Takatoh J, Thompson PM, He Z, Prevosto V, Wang F. Sci Adv. 2022 Nov 18;8(46):eabn6530. doi: 10.1126/sciadv.abn6530. Epub 2022 Nov 16.
Nature Communications
Microglia coordinate cellular interactions during spinal cord repair in mice
Brennan FH, Li Y, Wang C, Ma A, Guo Q, Li Y, Pukos N, Campbell WA, Witcher KG, Guan Z, Kigerl KA, Hall JCE, Godbout JP, Fischer AJ, McTigue DM, He Z, Ma Q, Popovich PG. Nat Commun. 2022 JUL 14;13(1):4096. doi: 10.1038/s41467-022-31797-0.
Neuron
Core Transcription Programs Controlling Injury-Induced Neurodegeneration of Retinal Ganglion Cells
Tian F, Cheng Y, Zhou S, Wang Q, Monavarfeshani A, Gao K, Jiang W, Kawaguchi R, Wang Q, Tang M, Donahue R, Meng H, Zhang Y, Jacobi A, Yan W, Yin J, Cai X, Yang Z, Hegarty S, Stanicka J, Dmitriev P, Taub D, Zhu J, Woolf CJ, Sanes JR, Geschwind DH, He Z. Neuron. 2022 Aug 17;110(16):2607-2624.e8. doi: 10.1016/j.neuron.2022.06.003. Epub 2022 Jun 28.
Neuron
Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells
Jacobi A, Tran NM, Yan W, Benhar I, Tian F, Schaffer R, He Z, Sanes JR. Neuron. 2022 Aug 17;110(16):2625-2645.e7. doi: 10.1016/j.neuron.2022.06.002. Epub 2022 Jun 28. PMID: 35767994
Neuron
Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy
Harbauer AB, Hees JT, Wanderoy S, Segura I, Gibbs W, Cheng Y, Ordonez M, Cai Z, Cartoni R, Ashrafi G, Wang C, Perocchi F, He Z, Schwarz TL. Neuron. 2022 Feb 19:S0896-6273(22)00105-2. doi: 10.1016/j.neuron.2022.01.035.
2021 Publications
Cold Spring Harb Perspect Biol.
Axon Regeneration: A Subcellular Extension in Multiple Dimensions.
Winter CC, He Z, Jacobi A. Cold Spring Harb Perspect Biol. 2022 Mar 1;14(3):a040923. doi: 10.1101/cshperspect.a040923.
eNeuro
MyelTracer: A Semi-Automated Software for Myelin g-Ratio Quantification.
Kaiser T, Allen HM, Kwon O, Barak B, Wang J, He Z, Jiang M, Feng G. eNeuro. 2021 Jul 21;8(4):ENEURO.0558-20.2021. doi: 10.1523/ENEURO.0558-20.2021.
Science
Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks.
Pederick DT, Lui JH, Gingrich EC, Xu C, Wagner MJ, Liu Y, He Z, Quake SR, Luo L. Science. 2021 Jun 4;372(6546):1068-1073. doi: 10.1126/science.abg1774.
Nature Communications
Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury.
Brommer, B, He, M., Zhang, Z., Yang, Z., Page, J., Su, J., Zhang, Y., Zhu, Gouy, E., Tang, J., Williams, P., Solinsky, R., Chen, B., He. Z. Nature Communications (2021)12:781
2020 Publications
Nature
Reprogramming to recover youthful epigenetic information and restore vision.
Lu, Y., Brommer, B., Tian, X., Krishnan, A., Meer, M., Wang, C., Vera, D.L., Zeng, Q., Yu, D., Bonkowski, M.S., Yang, J.H., Zhou, Z., Hoffmann, E.M., Karg, M.M., Schultz, M.B., Kane, A.E., Davidsohn, N., Korobkina, E., Chwalek, K., Rajman, L.A., Church, G.M., Hochedlinger, K., Gladyshev, V.N., Horvath, S., Levine, M.E., Gregory-Ksander, M., Ksander, B., He, Z. and Sinclair, D.A. Nature 588, 124-129 (2020).
Neuron
Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia.
Wang J, He X, Meng H, Li Y, Dmitriev P, Tian F, Page JC, Lu QR, He Z. Neuron. 2020 Oct 23:S0896-6273(20)30716-9. doi: 10.1016/j.neuron.2020.09.016. Online ahead of print. PMID: 33108748
Nature
Neonatal microglia-organized scar-free spinal cord repair.
Li, Y., He, X., Kawaguchi, R., Zhang, Y., Wang, Q., Monavarfeshani A., Yang, Z., Chen, B., Shi, Z., Meng, H., Zhou, S., Zhu, J., Jacobi, A., Swarup, V., Popovich, P.G., Geschwind, D.H., He, Z. Nature 2020 Oct 7. doi: 10.1038/s41586-020-2795-6. PMID: 33029008
Investigative Ophthalmology & Visual Science
Activating Transcription Factor 3 (ATF3) Protects Retinal Ganglion Cells and Promotes Functional Preservation After Optic Nerve Crush.
Kole C, Brommer B, Nakaya N, Sengupta M, Bonet-Ponce L, Zhao T, Wang C, Li W, He Z, Tomarev S. Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):31.
Current Opinion in Neurobiology
Viral vectors for neuronal cell type-specific visualization and manipulations.
Liu Y, Hegarty S, Winter C, Wang F, He Z. Curr Opin Neurobiol. 2020 Aug;63:67-76. doi: 10.1016/j.conb.2020.03.011. Epub 2020 Apr 25. PMID: 32344323. Review.
Expert Opinion On Therapeutic Targets
Targeting KCC2 for the treatment of disorders of neuronal hyperexcitability: preclinical insights.
Duy, P.Q., He, M., He, Z., and Kahle, K. Expert Opinion On Therapeutic Targets 2020 May 5:1-9. doi: 10.1080/14728222.2020.1762174.
Nature Cell Biology
LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control.
Gan W, Dai X, Dai X, Xie J, Yin S, Zhu J, Wang C, Liu Y, Guo J, Wang M, Liu J, Hu J, Quinton RJ, Ganem NJ, Liu P, Asara JM, Pandolfi PP, Yang Y, He Z, Gao G, Wei W. Nat Cell Biol. 2020 02; 22(2):246-256.
2019 Publications
Neuron
Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes.
Tran NM, Shekhar K, Whitney IE, Jacobi A, Benhar I, Hong G, Yan W, Adiconis X, Arnold ME, Lee JM, Levin JZ, Lin D, Wang C, Lieber CM, Regev A, He Z, Sanes JR. Neuron 104, 1039-1055, 2019
Neuron
Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs.
Zhang Y, Williams PR, Jacobi A, Wang C, Goel A, Hirano AA, Brecha NC, Kerschensteiner D, He Z. Neuron 2019 May 15. pii: S0896-6273(19)30390-3. doi: 10.1016/j.neuron.2019.04.033.
Nature Neuroscience
Neuronal deletion of Gtf2i, a gene in the Williams syndrome critical region, leads to myelination defects that can be rescued by clemastine.
Barak, B., Zhang, Z., Liu, Y., Nir, A., Trangle, S.S., Ennis, M., Levandowski, K.M., Wang, D., Quast, K., Boulting, G.L., Li, Y., Bayarsaihan, D., He, Z. and Feng, G. Nature Neurosci. 22, 700-708, 2019.
2018 Publications
Nature
Touch and tactile neuropathic pain sensitivity are set by corticospinal projections.
Liu, Y., Latremoliere, A., Li, X., Zhang, Z., Chen, M., Fang, C., Alexandre, C., Gao, Z., Chen, B., Ding, X., Zhou, J-Y., Zhang, Y., Chen, C., Wang, K.H., Woolf, C.J., and He, Z. Nature 561, 547-550, 2018
Cell
Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations.
Chen, B., Li, Y., Yu, B., Zhang, Z., Brommer, B., Williams, P.R., Liu, Y., Hegarty, S.V.., Zhou, S., Zhu, J., Guo, H., Lu, Y, Gu, X., and He, Z. Cell 174, 521-535, 2018
Nature
Required growth facilitators propel axon regeneration across complete spinal cord injury.
Anderson, M.A., O”Shea, T.M., Burda, J.E., Ao, Y., Barlatey, S.L., Bernstein, A.M., Kim, J.H., James, N.D., Rogers, A., Kato, B., Wollenberg, A.L., Kawaguchi, R., Coppola, G., Wang, C., Deming, T.J., He, Z., Courtine, G., Sofroniew, M.V. Nature 2018 Aug 29. doi: 10.1038/s41586-018-0467-6.
2017 Publications
Cell
Deconstruction of corticospinal circuits for goal-directed motor skills.
Wang, X., Liu, Y., Li, X., Zhang, Z., Yang, H., Zhang, Y., Williams, P.R., Alwahab, N., Kapur, K., Yu, B., Zhang, Y., Gerfen, C.R., Wang, K.H., and He. Z. Cell 171, 440-455, 2017.
Neuron
An Intrinsic Epigenetic Barrier for Functional Axon Regeneration.
Weng YL, An R, Cassin J, Joseph J, Mi R, Wang C, Zhong C, Jin SG, Pfeifer GP, Bellacosa A, Dong X, Hoke A, He Z, Song H, Ming GL. Neuron. 2017 Apr 19;94(2):337-346.
Neuron
Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others.
Norsworthy MW, Bei F, Kawaguchi R, Wang Q, Tran NM, Li Y, Brommer B, Zhang Y, Wang C, Sanes JR, Coppola G, He Z. Neuron. 2017 Jun 21;94(6):1112-1120.
Neuron
A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions.
Liu Y, Wang X, Li W, Zhang Q, Li Y, Zhang Z, Zhu J, Chen B, Williams PR, Zhang Y, Yu B, Gu X, He Z. Neuron. 95, 817-833, 2017.
Experimental Neurology
Reaching the brain: Advances in optic nerve regeneration.
Benowitz LI, He Z, Goldberg JL. 19. Exp. Neurol 287, 365-373, 2017. Review.
Experimental Neurology
Evolutionary perspectives: Introduction to the special issue on Axon Regeneration Across Species.
He Z, Höke A. Exp Neurol. 2017 Jan;287(Pt 3):299. (Editorial).
2016 Publications
Neuron
Intrinsic Control of Axon Regeneration.
Z. He and Y. Jin. Neuron 90, 437-451, 2016. Review.
Cell
Restoration of visual function by enhancing conduction in regenerated axons.
Bei, F., Lee, H.H.C., Liu, X., Gunner, G., Jin, H., Ma, L., Wang, C., Hou, L., Hensch, T.K., Frank, E., Sanes, J.R., Chen, C., Fagiolini, M., and He, Z. Cell 164, 219-232, 2016.
Journal of Comparative Neurology
Variable laterality of corticospinal tract axons that regenerate after spinal cord injury as a result of PTEN deletion or knock-down.
Willenberg R, Zukor K, Liu K, He Z, Steward O. J Comp Neurol. 524, 2654-2676, 2016.
Neuron
A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program.
Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, Horvath S, He Z, Benowitz L, Fainzilber M, Tuszynski M, Woolf CJ, Geschwind DH. Neuron. 2016 Mar 2;89(5):956-70.
Journal of Comparative Neurology
Retinal Ganglion Cell Survival and Axon Regeneration after Optic Nerve Injury in Naked Mole-Rats.
Park, K.K., LUo, X., Mooney, S.J., Yungher, B.J., Belin, S., Wang, C., Holmes, M.M., and He, Z. J. Comp Neurol 525, 380-388, 2016.
Nature Neuroscience
Neural activity promotes long-distance, target-specific regeneration of adult retinal axons.
Lim JA, Stafford BK, Nguyen PL, Lien BV, Wang C, Zukor K, He Z, Huberman AD. Nat Neurosci. 19, 1073-1084, 2016.
Neuron
The mammalian specific protein Armcx1 regulates mitochondria transport during axon regeneration.
Cartoni, R., Northsworthy, M.W., Bei, F., Wang, C., Li, S., Zgang, Y., Gabel, C.V., Schwarz, T.L., and He, Z. Neuron 94, 337-346, 2016.
2015 Publications
Neuron
Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling.
Duan, X., Qiao, M, Bei, F., Kim, I-J., He, Z and Sanes, J.R. Neuron 85, 1244-1256, 2015.
Neuron
Injury induced decline of intrinsic regenerative ability revealed by quantitative proteomics.
Belin, S., Nawabi, H., Wang, C., Warren, P., Latremoliere, A., Schorle, H., Uncu, C., Wool, C., He, Z and Steen, J. Neuron 86, 1000-1014, 2015.
Journal of Neuroscience
Effects of PTEN and Nogo codeletion on corticospinal axon sprouting and regeneration in mice.
Geoffroy, C.G., Lorenzana, A.O., Kwan, J.P., Lin, K., Ghassemi, O., Ma, A., Xu, N., Greger, D., He, Z., and Zheng, B. J. Neurosci. 35, 6413-6428 (2015).
Neuron
Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.
Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ. Neuron 86, 1215-1227, 2015.
Nature Communications
Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3.
Jin, D., Liu, Y., Sun, F., Wang X., Liu, X., and He, Z. Nature Commun. 2015 Nov 24;6:8074.
Neuron
Doublecortin-like kinases promote neuronal survival and induce growth cone reformation via distinct mechanisms.
Nawabi, H., Belin, S., Cartoni, R., Williams, P.R., Wang, C., Latremolière, A., Wang, X., Fu, X., Zhu, J., Taub, D.G., Yu, B., Gu, X., Woolf, C.J., Liu, J.S., Gabel, C.V., Steen, J. A., and He, Z. Neuron 88, 704-719, 2015.
2014 Publications
Exp Med
B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS.
O’Donovan KJ, Ma K, Guo H, Wang C, Sun F, Han SB, Kim H, Wong JK, Charron J, Zou H, Son YJ, He Z, Zhong J. J Exp Med. 211, 801-814, 2014.
Journal of Neuroscience
Characterization of long-descending pre-motor propriospinal neurons in the spinal cord.
Ni, Y, Nawabi, H., Liu, X., Yang, L., Miyamichi, K., Tedeschi, A., Xu, B., Wall, N. R., Callaway, E. M., and He, Z. J. Neurosci. 34, 9404-9417, 2014.
Cell Metabolism
Independent control of aging and axon regeneration.
Belin S, Norsworthy M, He Z. Cell Metabolism 19, 354-356, 2014. Review.
Current Opinion Neurobiology
Molecular mechanisms of intrinsic growth ability.
L. Lu and He, Z. Curr Opin Neurobiol 27C: 135-142, 2014. Review.
2013 Publications
Journal of Neuroscience
Short hairpin RNA against PTEN enhances intrinsic growth of corticospinal tract axons after spinal cord injury.
Zukor, K., Belin, S., Wang, C., Keelan, N., Wang, X., and He, Z. J. Neurosci. 33, 15350-15261, 2013.
2012 Publications
Neuron
Differential Effects of Unfolded Protein Response Pathways on Axon Injury-induced Death of Retinal Ganglion Cells.
Hu, Y., Park, K.K., Yang, L., Wei, X., Yang, Q, Thielen, P., Lee, A-H., Cartoni, R., Glimcher, L. H., Chen, D.F., and He, Z. Neuron 73: 445-452, 2012.
Genes & Development
No simpler than mammals: axon and dendrite regeneration in Drosophila.
Nawabi, H, Zukor, K, and He, Z. Genes Dev. 26:1509-1514, 2012. Review.
2011 Publications
Nature
Cortical representation of olfactory bulb input revealed by retrograde mono-transsynaptic labeling.
Miyamichi K, Amat F, Mousavi F, Wang C, Wickersham I, Wall N, Taniguchi H, Huang ZJ, He, Z., Callaway, E. M., Horowitz, M. A., and L. Luo. Nature 472, 191-196, 2011.
Nature
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3.
Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z. Nature 2011 480, 372-375, 2011.
Annual Review of Neuroscience
Intrinsic controls of axon regeneration.
Liu K, Tedeschi K, Park, He Z. Ann Rev Neurosci 34, 131-152, 2011. Review.
Nature
Regenerative medicine: drawing breath after spinal injury.
Zukor K, He Z. Nature 13;475:177-1778, 2011. Review.
2010 Publications
Nature Neuroscience
PTEN deletion enhances the regenerative ability of adult corticospinal neurons.
Liu K, Lu Y, Lee JK, Samara R, Willenberg R, Sears-Kraxberger I, Tedeschi A, Park KK, Jin D, Cai B, Xu B, Connolly L, Steward O, Zheng B, He Z. Nat Neurosci 2010:13(9):1075-1081.
2009 Publications
Science
PTP{sigma} is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration.
Shen Y, Tenney AP, Busch SA, Horn KP, Cuascut FX, Liu K, He Z, Silver J, Flanagan JG. Science 2009;326(5952):592-596.
Neuron
SOCS3 deletion promotes optic nerve regeneration in vivo.
Smith PD, Sun F, Park K, Cai B, Wang C, Kuwako K, Martinez-Carrasco I, Connolly L, He Z. Neuron 2009;64(5):617-623.
2008 Publications
Science
Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway.
Park K, Liu K, Hu Y, Smith P, Chen W, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z. Science 2008;322:963-966.
Molecular and Cellular Neuroscience
Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury.
Ji B, Case LC, Liu K, Shao Z, Lee X, Yang Z, Wang J, Tian T, Shulga-Morskaya S, Scott M, He Z, Relton JK, Mi S. Mol Cell Neurosci 2008;39(2):258-267.
Journal of Biological Chemistry
The role of Kalirin9 in p75/nogo receptor-mediated RhoA activation in cerebellar granule neurons.
Harrington AW, Li QM, Tep C, Park JB, He Z, Yoon SO. J Biol Chem 2008;283(36):24690-24697.
2007 Publications
Journal of Neuroscience
The Nogo-66 receptor NgR1 is required only for the acute growth cone-collapsing but not the chronic growth-inhibitory actions of myelin inhibitors.
Chivatakarn O, Kaneko S, He Z, Tessier-Lavigne M, Giger RJ. J Neurosci 2007;27(27):7117-7124.
2006 Publications
Journal of Neuroscience
Protecting Axonal Degeneration by Increasing NAD Levels in Experimental Autoimmune Encephalomyelitis Models.
Kaneko S, Wang J, Kaneko M, Yiu G, Hurrell J, Chitnis T, Khoury SJ, He Z. J Neurosci 2006;26(38):9794-9804.
Nature Reviews Neuroscience
Glial inhibition of CNS axon regeneration.
Yiu G, He Z. Nature Rev Neurosci 2006;7:617-627. Review.
2005 Publications
Neuron
A TNF receptor family member TROY is a co-receptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors.
Park J, Yiu G, Kaneko S, Wang J, Chang J, He Z. Neuron 2005;45:345-351.
Nature Neuroscience
LINGO-1 negatively regulates myelination by oligodendrocytes.
Mi S, Miller RH, Lee X, Scott ML, Shulag-Morskaya S, Shao Z, Chang J, Thill G, Levesque M, Zhang M, Hession C, Sah D, Trapp B, He Z, Jung V, McCoy JM, Pepinsky RB. Nat Neurosci 2005;8:745-751.
Journal of Cell Biology
Mediation of NAD-dependent axon degeneration protection by a local mechanism.
Wang J, Zhai Q, Chen Y, He Z. J Cell Biol 2005;170(3):349-355.
Science
EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans.
Koprivica V, Cho KS, Park JB, Yiu G, Atwal J, Gore B, Kim JA, Lin E, Tessier-Lavigne M, Chen DF, He Z. Science 2005;310:106-110.
2004 Publications
Journal of Neuroscience
Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state.
Fischer D, He Z, Benowitz LI. J Neurosci 2004;24:1646-1652.
Nature Neuroscience
PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration.
Sivasankaran R, Pei J, Wang KC, Zhang YP, Shields CB, Xu X-M, He Z. Nature Neurosci 2004;7:261-268.
Annual Review Neuroscience
The Nogo Signaling Pathway for Regeneration Block.
He Z, Koprivica V. Ann Review Neurosci 2004;27:341-368. Review.
2003 Publications
Neuron
Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration.
Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z. Neuron 2003;39:217-225.
2002 Publications
Nature
Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth.
Wang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL, He Z. Nature 2002;417:941-944.
Neuron
Myelin-Associated Glycoprotein Interacts with the Nogo66 Receptor to Inhibit Neurite Outgrowth.
Domeniconi M, Cao Z, Spencer T, Sivasankaran R, Wang KC, Nikulina E, Kimura N, Cai H, Deng K, Gao Y, He Z, Filbin MT. Neuron 2002;35:283-290.
Nature
p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.
Wang KC, Kim JA, Sivasankaran R, Segal R, He Z. Nature 2002;420:74-78.
Molecular and Cellular Neuroscience
Immunization with myelin or recombinant Nogo-66/MAG in alum promotes axon regeneration and sprouting after corticospinal tract lesions in the spinal cord.
Sicotte M, Tsatas O, Jeong SY, Cai CQ, He Z, David S. Mol Cell Neurosci 2002;23:251-263.
Neuron
Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition.
He XL, Bazan JF, McDermott G, Park JB, Wang K, Tessier-Lavigne M, He Z, Garcia KC. Neuron 2002;38:177-185.
2000 Publications
PNAS
The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand dependent manner.
Vikis HG, Li W, He Z, Guan K-L. PNAS 2000;97;12457-12462.
1999 Publications
Journal of Neurochemistry
Semaphorins as mediators of neuronal apoptosis.
Shirvan A, Ziv I, Fleminger G, He Z, Brudo I, Melamed E, Barzilai A. J Neurochem 1999;73:961-971.
Cell
Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates.
Tamagnone L, Artigiani S, Chen H, He Z, Ming G-L, Song H-J, Chedotal A, Winberg ML, Goodman CS, Poo M-M, Tessier-Lavigne M, Comoglio PM. Cell 1999;99:71-80.
1998 Publications
Science
Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.
Song H-J, Ming G-L, He Z, Lehmann M, McKerracher L, Tessier-Lavigne M, Poo M-M. Science 1998;281:1515-1518.
Development
Semaphorins III and IV repel hippocampal axons via two distinct receptors.
Chedotal A, Del Rio JA, Ruiz M, He Z, Borrell V, de Castro F, Ezan F, Goodman CS, Tessier-Lavigne M, Sotelo C, Soriano E. Development 1998;125:4313-4323.
Neuron
Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins.
Chen H, He Z, Bagri A, Tessier-Lavigne M. Neuron 1998;21:1283-1290.
1997 Publications
Cell
Neuropilin is a receptor for the axonal chemorepellent Semaphorin III.
He Z, Tessier-Lavigne M. Cell 1997;90(4): 739-751.
Neuron
Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III.
Chen H, Chedotal A, He Z, Goodman CS, Tessier-Lavigne M. Neuron 1997;19(3), 547-559.
Nucleic Acids Research
Isolation of human complexes proficient in nucleotide excision repair.
He Z, Ingles CJ. Nucleic Acids Res 1997;25(6):1136-1141.
Biochemistry
Role of protein-protein interactions in the function of replication protein A (RPA): RPA modulates the activity of DNA polymerase a by multiple mechanisms.
Braun KA, Lao Y, He Z, Ingles CJ, Wold MS. Biochemistry 1997;36(28):8443-8454.
1996 Publications
Journal of Biological Chemistry
Yeast replication protein A (RPA) is required for nucleotide excision repair in vitro.
He Z, Wong JMS, Maniar HS, Brill SJ, and Ingles CJ. J Biol Chem 1996;271(45):28243-28249.
1995 Publications
Nature
RPA involvement in the damage-recognition and incision steps of nucleotide excision repair.
He Z, Henricksen LA, Wold MS, and Ingles CJ. Nature 1995;374(6522):566-569.
1994 Publications
Genomics
The structure of the human sterol carrier protein X/sterol carrier protein 2 gene (SCP2).
Ohba T, Rennert H, Pfeifer SM, He Z, Yamamoto R, Holt JA, Billheimer JT, Strauss III JF. Genomics 1994;24(2):370-374.
1993 Publications
Cell
The transactivator proteins VP16 and GAL4 bind replication factor A.
He Z, Brinton BT, Greenblatt J, Hassell JA, Ingles CJ. Cell 1993;73(6):1223-1232.
1991 Publications
DNA Cell Biology
cDNAs encoding members of a family of proteins related to human sterol carrier protein 2 and assignment of the gene to human chromosome 1 p21—-pter.
He Z, Yamamoto R, Furth EE, Schantz LJ, Naylor SL, George H, Billheimer JT, Strauss JF 3rd. DNA Cell Biol. 1991 Oct;10(8):559-69. doi: 10.1089/dna.1991.10.559. PMID: 1718316