In the Woolf lab, we study how different forms of neuronal plasticity contribute both to adaptive and maladaptive changes in the mammalian nervous system. We pay particular attention to the neurobiological processes associated with pain, neural regeneration and neurodegenerative diseases.

We have established functional and comparative genomic strategies using expression profiling, bioinformatics and gain- and loss-of-function approaches, to screen for novel genes that contribute to neuronal plasticity and disease phenotypes. Our group works closely with many academic groups, including those at Harvard Medical School, Harvard University, the Harvard Stem Cell Institute, the Broad Institute and the pharmaceutical industry.

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