{"id":57,"date":"2019-01-30T19:44:14","date_gmt":"2019-01-30T19:44:14","guid":{"rendered":"http:\/\/gillfishmanstaging.com\/kirby-template2\/?page_id=57"},"modified":"2025-08-25T16:22:10","modified_gmt":"2025-08-25T16:22:10","slug":"publications","status":"publish","type":"page","link":"https:\/\/kirbyneuro.org\/ZhigangHe\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”BKGD IMAGE” _builder_version=”4.7.4″ background_image=”https:\/\/kirbyneuro.org\/ZhigangHe\/wp-content\/uploads\/2020\/10\/he-page-banner-v2.1.jpg” background_position=”bottom_center” max_height=”225px” custom_margin=”0px||0px||true|false” custom_padding=”0px|0px|0px|0px|true|false” border_color_all=”rgba(0,0,0,0)” global_module=”3000″ global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_enable_color=”off” custom_padding=”90px|0px|60px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text module_id=”home_header” _builder_version=”4.16″ text_font=”||||||||” header_font=”||||||||” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||true|false” custom_css_main_element=”color:#ffffff;||line-height:0.95em;||font-family:el messiri;||font-size:44px;||font-weight:normal;” text_text_shadow_style=”preset3″ text_text_shadow_vertical_length=”0.03em” text_text_shadow_blur_strength=”0.1em” text_text_shadow_color=”#000000″ inline_fonts=”Merriweather,El Messiri,Georgia” global_colors_info=”{}”]<\/p>\n

The Zhigang He Laboratory<\/a><\/div>\n
at the FM Kirby Neurobiology Center<\/a><\/div>\n

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Lab Publications<\/div>\n

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2025 Publications<\/h2>\n

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Cell Reports<\/h5>\n

From thought to action: The organization of spinal projecting neurons<\/a><\/strong>
\nWinter CC, Wang KH, He Z. Cell Rep. 2025 Aug 14;44(8):116153. doi: 10.1016\/j.celrep.2025.116153. Epub ahead of print. PMID: 40818073.
\nDownload Paper<\/a><\/strong>
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Cell<\/h5>\n

Repeat-element RNAs integrate a neuronal growth circuit<\/a><\/strong>
\nZahavi EE, Koppel I, Kawaguchi R, Oses-Prieto JA, Briner A, Monavarfeshani A, Dalla Costa I, van Niekerk E, Lee J, Matoo S, Hegarty S, Donahue RJ, Sahoo PK, Ben-Dor S, Feldmesser E, Ryvkin J, Leshkowitz D, Perry RB, Cheng Y, Farber E, Abraham O, Samra N, Okladnikov N, Alber S, Albus CA, Rishal I, Ulitsky I, Tuszynski MH, Twiss JL, He Z, Burlingame AL, Fainzilber M. Cell. 2025 Aug 7;188(16):4350-4365.e22. doi: 10.1016\/j.cell.2025.04.030. Epub 2025 May 16. PMID: 40381624[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Nature Communications<\/h5>\n

Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration<\/a><\/strong>
\nHeo K, Ho TS, Zeng X, Turnes BL, Arab M, Jayakar S, Chen K, Kimourtzis G, Condro MC, Fazzari E, Song X, Tabitha Hees J, Xu Z, Chen X, Barrett LB, Perrault L, Pandey R, Zhang K, Bhaduri A, He Z, Kornblum HI, Hubbs J, Woolf CJ. Nat Commun. 2025 Mar 26;16(1):2975. doi: 10.1038\/s41467-025-58303-6. PMID: 40140393[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Nature Communications<\/h5>\n

Anisotropic Hydrogel Microelectrodes for Intraspinal Neural Recordings in vivo<\/a><\/strong>
\nHuang S, Xiao R, Lin S, Wu Z, Lin C, Jang G, Hong E, Gupta S, Lu F, Chen B, Liu X, Sahasrabudhe A, Zhang Z, He Z, Crosby AJ, Sumaria K, Liu T, Wang Q, Rao S. Nat Commun. 2025 Jan 28;16(1):1127. doi: 10.1038\/s41467-025-56450-4.[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”29px||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.24.2″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2024 Publications<\/h2>\n

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Cell<\/h5>\n

Spinal projecting neurons in rostral ventromedial medulla co-regulate motor and sympathetic tone<\/a><\/strong>
\nZhang Z, Su J, Tang J, Chung L, Page JC, Winter CC, Liu Y, Kegeles E, Conti S, Zhang Y, Biundo J, Chalif JI, Hua CY, Yang Z, Yao X, Yang Y, Chen S, Schwab JM, Wang KH, Chen C, Prerau MJ, He Z. Cell. 2024 May 3:S0092-8674(24)00447-1. doi: 10.1016\/j.cell.2024.04.022. Epub ahead of print. PMID: 38733990.[\/et_pb_text][et_pb_text _builder_version=”4.24.2″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Cell<\/h5>\n

Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration<\/a><\/strong>
\nLiu X, Xin DE, Zhong X, Zhao C, Li Z, Zhang L, Dourson AJ, Lee L, Mishra S, Bayat AE, Nicholson E, Seibel WL, Yan B, Mason J, Turner BJ, Gonsalvez DG, Ong W, Chew SY, Ghosh B, Yoon SO, Xin M, He Z, Tchieu J, Wegner M, Nave KA, Franklin RJM, Dutta R, Trapp BD, Hu M, Smith MA, Jankowski MP, Barton SK, He X, Lu QR. Cell. 2024 May 9;187(10):2465-2484.e22. doi: 10.1016\/j.cell.2024.04.005. Epub 2024 May 2. PMID: 38701782.[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”29px||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.23.1″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2023 Publications<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.23.1″ custom_padding=”29px||30px|||” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_image src=”https:\/\/kirbyneuro.org\/ZhigangHe\/wp-content\/uploads\/2023\/12\/Publication-nature-Carla.png” alt=”Neuron 110, 16″ title_text=”Publication-nature-Carla” url=”https:\/\/www.cell.com\/neuron\/issue?pii=S0896-6273(21)X0017-7″ _builder_version=”4.23.1″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.23.1″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Nature<\/h5>\n

A transcriptomic taxonomy of mouse brain-wide spinal projecting neurons<\/a><\/strong>
\nWinter C.C, Jacobi A, Su J, Chung L, van Velthoven C, Yao Z, Lee C, Zhang Z, Yu S, Gao K, Duque Salazar G, Kegeles E, Zhang Y, Tomihiro M, Zhang Y, Yang Z, Zhu J, Tang J, Song X, Donahue R, Wang Q, McMillen D, Kunst M, Wang N, Smith K, Romero G, Frank M,Krol A, Kawaguchi R, Geschwind D, Feng G, Goodrich L, Liu Y, Tasic B, Zeng H, He Z. Nature 624, 403\u2013414 (2023). https:\/\/doi.org\/10.1038\/s41586-023-06817-8[\/et_pb_text][et_pb_text _builder_version=”4.23.1″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]Collection Description: Brain Initiative Cell Census Network 2.0<\/a><\/strong>
\nThis study is part of part of a collection of papers for the Brain Initiative Cell Census Network 2.0(BICCN): The first complete cell census and atlas of a mammalian brain
\nSee the immersive collection of studies here:
\nhttps:\/\/www.nature.com\/immersive\/d42859-023-00069-2\/index.html<\/a><\/strong>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”29px||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.21.0″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Elife<\/h5>\n

Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons<\/a><\/strong>
\nPederick DT, Perry-Hauser NA, Meng H, He Z, Javitch JA, Luo L. Elife. 2023 Mar 20;12:e83529. doi: 10.7554\/eLife.83529.[\/et_pb_text][et_pb_text _builder_version=”4.21.0″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Nature Immunology<\/h5>\n

Temporal single-cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury<\/a><\/strong>
\nBenhar I, Ding J, Yan W, Whitney IE, Jacobi A, Sud M, Burgin G, Shekhar K, Tran NM, Wang C, He Z, Sanes JR, Regev A.
\nNat Immunol. 2023 Apr;24(4):700-713. doi: 10.1038\/s41590-023-01437-w. Epub 2023 Feb 20.[\/et_pb_text][et_pb_text _builder_version=”4.21.0″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

PNAS<\/h5>\n

Transcriptomic Analysis of the Ocular Posterior Segment Completes a Cell Atlas of the Human Eye<\/a><\/strong>
\nMonavarfeshani A, Yan W, Pappas C, Odenigbo KA, He Z, Segr\u00e8 AV, van Zyl T, Hageman GS, Sanes JR.
\nProc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2306153120. doi: 10.1073\/pnas.2306153120. Epub 2023 Aug 11. PMID: 37566633[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Nature Communications<\/h5>\n

The secondary somatosensory cortex gates mechanical and heat sensitivity<\/a><\/strong>
\nTaub DG, Jiang Q, Pietrafesa F, Su J, Carroll A, Greene C, Blanchard MR, Jain A, El-Rifai M, Callen A, Yager K, Chung C, He Z, Chen C, Woolf CJ. The secondary somatosensory cortex gates mechanical and heat sensitivity. Nat Commun. 2024 Feb 12;15(1):1289. doi: 10.1038\/s41467-024-45729-7. PMID: 38346995; PMCID: PMC10861531.[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”29px||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2022 Publications<\/h2>\n

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Science Advances<\/h5>\n

Somatosensory cortical signature of facial nociception and vibrotactile touch-induced analgesia<\/a><\/strong>
\nLu J, Chen B, Levy M, Xu P, Han BX, Takatoh J, Thompson PM, He Z, Prevosto V, Wang F. Sci Adv. 2022 Nov 18;8(46):eabn6530. doi: 10.1126\/sciadv.abn6530. Epub 2022 Nov 16.[\/et_pb_text][et_pb_text _builder_version=”4.17.4″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Nature Communications<\/h5>\n

Microglia coordinate cellular interactions during spinal cord repair in mice<\/a><\/strong>
\nBrennan FH, Li Y, Wang C, Ma A, Guo Q, Li Y, Pukos N, Campbell WA, Witcher KG, Guan Z, Kigerl KA, Hall JCE, Godbout JP, Fischer AJ, McTigue DM, He Z, Ma Q, Popovich PG. Nat Commun. 2022 JUL 14;13(1):4096. doi: 10.1038\/s41467-022-31797-0.[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.18.0″ custom_padding=”29px||30px|||” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_image src=”https:\/\/kirbyneuro.org\/ZhigangHe\/wp-content\/uploads\/2022\/08\/publication-neuron-110-16.jpg” alt=”Neuron 110, 16″ title_text=”publication-neuron-110-16″ url=”https:\/\/www.cell.com\/neuron\/issue?pii=S0896-6273(21)X0017-7″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Neuron<\/h5>\n

Core Transcription Programs Controlling Injury-Induced Neurodegeneration of Retinal Ganglion Cells <\/a><\/strong>
\nTian F, Cheng Y, Zhou S, Wang Q, Monavarfeshani A, Gao K, Jiang W, Kawaguchi R, Wang Q, Tang M, Donahue R, Meng H, Zhang Y, Jacobi A, Yan W, Yin J, Cai X, Yang Z, Hegarty S, Stanicka J, Dmitriev P, Taub D, Zhu J, Woolf CJ, Sanes JR, Geschwind DH, He Z. Neuron. 2022 Aug 17;110(16):2607-2624.e8. doi: 10.1016\/j.neuron.2022.06.003. Epub 2022 Jun 28.[\/et_pb_text][et_pb_text _builder_version=”4.17.4″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Neuron<\/h5>\n

Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells<\/a><\/strong>
\nJacobi A, Tran NM, Yan W, Benhar I, Tian F, Schaffer R, He Z, Sanes JR. Neuron. 2022 Aug 17;110(16):2625-2645.e7. doi: 10.1016\/j.neuron.2022.06.002. Epub 2022 Jun 28. PMID: 35767994[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”0px||30px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Neuron<\/h5>\n

Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy<\/a><\/strong>
Harbauer AB, Hees JT, Wanderoy S, Segura I, Gibbs W, Cheng Y, Ordonez M, Cai Z, Cartoni R, Ashrafi G, Wang C, Perocchi F, He Z, Schwarz TL. Neuron. 2022 Feb 19:S0896-6273(22)00105-2. doi: 10.1016\/j.neuron.2022.01.035.<\/p>\n

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2021 Publications<\/h2>\n

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Cold Spring Harb Perspect Biol.<\/h5>\n

Axon Regeneration: A Subcellular Extension in Multiple Dimensions. <\/a><\/strong>
\nWinter CC, He Z, Jacobi A. Cold Spring Harb Perspect Biol. 2022 Mar 1;14(3):a040923. doi: 10.1101\/cshperspect.a040923.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

eNeuro<\/h5>\n

MyelTracer: A Semi-Automated Software for Myelin g-Ratio Quantification. <\/a><\/strong>
\nKaiser T, Allen HM, Kwon O, Barak B, Wang J, He Z, Jiang M, Feng G. eNeuro. 2021 Jul 21;8(4):ENEURO.0558-20.2021. doi: 10.1523\/ENEURO.0558-20.2021.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Science<\/h5>\n

Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks.<\/a><\/strong>
\nPederick DT, Lui JH, Gingrich EC, Xu C, Wagner MJ, Liu Y, He Z, Quake SR, Luo L. Science. 2021 Jun 4;372(6546):1068-1073. doi: 10.1126\/science.abg1774.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Nature Communications<\/h5>\n

Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury.<\/a><\/strong>
Brommer, B, He, M., Zhang, Z., Yang, Z., Page, J., Su, J., Zhang, Y., Zhu, Gouy, E., Tang, J., Williams, P., Solinsky, R., Chen, B., He. Z. Nature Communications (2021)12:781<\/p>\n

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2020 Publications<\/h2>\n

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Nature<\/h5>\n

Reprogramming to recover youthful epigenetic information and restore vision.<\/a><\/strong>
\nLu, Y., Brommer, B., Tian, X., Krishnan, A., Meer, M., Wang, C., Vera, D.L., Zeng, Q., Yu, D., Bonkowski, M.S., Yang, J.H., Zhou, Z., Hoffmann, E.M., Karg, M.M., Schultz, M.B., Kane, A.E., Davidsohn, N., Korobkina, E., Chwalek, K., Rajman, L.A., Church, G.M., Hochedlinger, K., Gladyshev, V.N., Horvath, S., Levine, M.E., Gregory-Ksander, M., Ksander, B., He, Z. and Sinclair, D.A. Nature 588, 124-129 (2020). [\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Neuron<\/h5>\n

Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia.<\/a><\/strong>
Wang J, He X, Meng H, Li Y, Dmitriev P, Tian F, Page JC, Lu QR, He Z. Neuron. 2020 Oct 23:S0896-6273(20)30716-9. doi: 10.1016\/j.neuron.2020.09.016. Online ahead of print. PMID: 33108748<\/p>\n

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Nature<\/h5>\n

Neonatal microglia-organized scar-free spinal cord repair.<\/strong><\/a>
Li, Y., He, X., Kawaguchi, R., Zhang, Y., Wang, Q., Monavarfeshani A., Yang, Z., Chen, B., Shi, Z., Meng, H., Zhou, S., Zhu, J., Jacobi, A., Swarup, V., Popovich, P.G., Geschwind, D.H., He, Z. Nature 2020 Oct 7. doi: 10.1038\/s41586-020-2795-6. PMID: 33029008<\/p>\n

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Investigative Ophthalmology & Visual Science<\/h5>\n

Activating Transcription Factor 3 (ATF3) Protects Retinal Ganglion Cells and Promotes Functional Preservation After Optic Nerve Crush.<\/strong><\/a>
Kole C, Brommer B, Nakaya N, Sengupta M, Bonet-Ponce L, Zhao T, Wang C, Li W, He Z, Tomarev S. Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):31.<\/p>\n

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Current Opinion in Neurobiology<\/h5>\n

Viral vectors for neuronal cell type-specific visualization and manipulations.<\/strong><\/a>
Liu Y, Hegarty S, Winter C, Wang F, He Z. Curr Opin Neurobiol. 2020 Aug;63:67-76. doi: 10.1016\/j.conb.2020.03.011. Epub 2020 Apr 25. PMID: 32344323. Review.<\/p>\n

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Expert Opinion On Therapeutic Targets<\/h5>\n

Targeting KCC2 for the treatment of disorders of neuronal hyperexcitability: preclinical insights.<\/strong><\/a>
Duy, P.Q., He, M., He, Z., and Kahle, K. Expert Opinion On Therapeutic Targets 2020 May 5:1-9. doi: 10.1080\/14728222.2020.1762174.<\/p>\n

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Nature Cell Biology<\/h5>\n

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control.<\/strong><\/a>
\nGan W, Dai X, Dai X, Xie J, Yin S, Zhu J, Wang C, Liu Y, Guo J, Wang M, Liu J, Hu J, Quinton RJ, Ganem NJ, Liu P, Asara JM, Pandolfi PP, Yang Y, He Z, Gao G, Wei W. Nat Cell Biol. 2020 02; 22(2):246-256.[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”0px||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”0|0px|47.625px|0px|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_padding=”29px||30px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2019 Publications<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”0px||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Neuron<\/h5>\n

Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes.<\/strong><\/a>
Tran NM, Shekhar K, Whitney IE, Jacobi A, Benhar I, Hong G, Yan W, Adiconis X, Arnold ME, Lee JM, Levin JZ, Lin D, Wang C, Lieber CM, Regev A, He Z, Sanes JR. Neuron 104, 1039-1055, 2019<\/p>\n

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Neuron<\/h5>\n

Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs.<\/a><\/strong>
\nZhang Y, Williams PR, Jacobi A, Wang C, Goel A, Hirano AA, Brecha NC, Kerschensteiner D, He Z. Neuron 2019 May 15. pii: S0896-6273(19)30390-3. doi: 10.1016\/j.neuron.2019.04.033.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Nature Neuroscience<\/h5>\n

Neuronal deletion of Gtf2i, a gene in the Williams syndrome critical region, leads to myelination defects that can be rescued by clemastine.<\/strong><\/a>
Barak, B., Zhang, Z., Liu, Y., Nir, A., Trangle, S.S., Ennis, M., Levandowski, K.M., Wang, D., Quast, K., Boulting, G.L., Li, Y., Bayarsaihan, D., He, Z. and Feng, G. Nature Neurosci. 22, 700-708, 2019.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”0px||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”0|0px|47.625px|0px|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_padding=”29px||30px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2018 Publications<\/h2>\n

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Nature<\/h5>\n

Touch and tactile neuropathic pain sensitivity are set by corticospinal projections.<\/strong><\/a>
Liu, Y., Latremoliere, A., Li, X., Zhang, Z., Chen, M., Fang, C., Alexandre, C., Gao, Z., Chen, B., Ding, X., Zhou, J-Y., Zhang, Y., Chen, C., Wang, K.H., Woolf, C.J., and He, Z. Nature 561, 547-550, 2018<\/p>\n

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Cell<\/h5>\n

Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations.<\/strong><\/a>
Chen, B., Li, Y., Yu, B., Zhang, Z., Brommer, B., Williams, P.R., Liu, Y., Hegarty, S.V.., Zhou, S., Zhu, J., Guo, H., Lu, Y, Gu, X., and He, Z. Cell 174, 521-535, 2018<\/p>\n

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Nature<\/h5>\n

Required growth facilitators propel axon regeneration across complete spinal cord injury.<\/strong><\/a>
Anderson, M.A., O\u201dShea, T.M., Burda, J.E., Ao, Y., Barlatey, S.L., Bernstein, A.M., Kim, J.H., James, N.D., Rogers, A., Kato, B., Wollenberg, A.L., Kawaguchi, R., Coppola, G., Wang, C., Deming, T.J., He, Z., Courtine, G., Sofroniew, M.V. Nature 2018 Aug 29. doi: 10.1038\/s41586-018-0467-6.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”0px||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2017 Publications<\/h2>\n

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Cell<\/h5>\n

Deconstruction of corticospinal circuits for goal-directed motor skills.<\/strong><\/a>
Wang, X., Liu, Y., Li, X., Zhang, Z., Yang, H., Zhang, Y., Williams, P.R., Alwahab, N., Kapur, K., Yu, B., Zhang, Y., Gerfen, C.R., Wang, K.H., and He. Z. Cell 171, 440-455, 2017.<\/p>\n

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Neuron<\/h5>\n

An Intrinsic Epigenetic Barrier for Functional Axon Regeneration.<\/strong><\/a>
Weng YL, An R, Cassin J, Joseph J, Mi R, Wang C, Zhong C, Jin SG, Pfeifer GP, Bellacosa A, Dong X, Hoke A, He Z, Song H, Ming GL. Neuron. 2017 Apr 19;94(2):337-346.<\/p>\n

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Neuron<\/h5>\n

Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others.<\/strong><\/a>
Norsworthy MW, Bei F, Kawaguchi R, Wang Q, Tran NM, Li Y, Brommer B, Zhang Y, Wang C, Sanes JR, Coppola G, He Z. Neuron. 2017 Jun 21;94(6):1112-1120.<\/p>\n

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Neuron<\/h5>\n

A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions.<\/strong><\/a>
Liu Y, Wang X, Li W, Zhang Q, Li Y, Zhang Z, Zhu J, Chen B, Williams PR, Zhang Y, Yu B, Gu X, He Z. Neuron. 95, 817-833, 2017.<\/p>\n

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Experimental Neurology<\/h5>\n

Reaching the brain: Advances in optic nerve regeneration.<\/strong><\/a>
\nBenowitz LI, He Z, Goldberg JL. 19. Exp. Neurol 287, 365-373, 2017. Review.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Experimental Neurology<\/h5>\n

Evolutionary perspectives: Introduction to the special issue on Axon Regeneration Across Species.<\/strong><\/a>
He Z, H\u00f6ke A. Exp Neurol. 2017 Jan;287(Pt 3):299. (Editorial).<\/p>\n

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2016 Publications<\/h2>\n

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Neuron<\/h5>\n

Intrinsic Control of Axon Regeneration.<\/strong><\/a>
Z. He and Y. Jin. Neuron 90, 437-451, 2016. Review.<\/p>\n

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Cell<\/h5>\n

Restoration of visual function by enhancing conduction in regenerated axons.<\/strong><\/a>
Bei, F., Lee, H.H.C., Liu, X., Gunner, G., Jin, H., Ma, L., Wang, C., Hou, L., Hensch, T.K., Frank, E., Sanes, J.R., Chen, C., Fagiolini, M., and He, Z. Cell 164, 219-232, 2016.<\/p>\n

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Journal of Comparative Neurology<\/h5>\n

Variable laterality of corticospinal tract axons that regenerate after spinal cord injury as a result of PTEN deletion or knock-down.<\/strong><\/a>
\nWillenberg R, Zukor K, Liu K, He Z, Steward O. J Comp Neurol. 524, 2654-2676, 2016.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Neuron<\/h5>\n

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program.<\/strong><\/a>
Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, Horvath S, He Z, Benowitz L, Fainzilber M, Tuszynski M, Woolf CJ, Geschwind DH. Neuron. 2016 Mar 2;89(5):956-70.<\/p>\n

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Journal of Comparative Neurology<\/span><\/h5>\n

Retinal Ganglion Cell Survival and Axon Regeneration after Optic Nerve Injury in Naked Mole-Rats.<\/strong><\/a>
Park, K.K., LUo, X., Mooney, S.J., Yungher, B.J., Belin, S., Wang, C., Holmes, M.M., and He, Z. J. Comp Neurol 525, 380-388, 2016.<\/p>\n

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Nature Neuroscience<\/h5>\n

Neural activity promotes long-distance, target-specific regeneration of adult retinal axons.<\/a><\/strong>
\nLim JA, Stafford BK, Nguyen PL, Lien BV, Wang C, Zukor K, He Z, Huberman AD. Nat Neurosci. 19, 1073-1084, 2016.<\/p>\n

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Neuron<\/h5>\n

The mammalian specific protein Armcx1 regulates mitochondria transport during axon regeneration.<\/strong><\/a>
Cartoni, R., Northsworthy, M.W., Bei, F., Wang, C., Li, S., Zgang, Y., Gabel, C.V., Schwarz, T.L., and He, Z. Neuron 94, 337-346, 2016.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2015 Publications<\/h2>\n

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Neuron<\/h5>\n

Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling.<\/strong><\/a>
Duan, X., Qiao, M, Bei, F., Kim, I-J., He, Z and Sanes, J.R. Neuron 85, 1244-1256, 2015.<\/p>\n

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Neuron<\/h5>\n

Injury induced decline of intrinsic regenerative ability revealed by quantitative proteomics.<\/a><\/strong>
Belin, S., Nawabi, H., Wang, C., Warren, P., Latremoliere, A., Schorle, H., Uncu, C., Wool, C., He, Z and Steen, J. Neuron 86, 1000-1014, 2015.<\/p>\n

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Journal of Neuroscience<\/h5>\n

Effects of PTEN and Nogo codeletion on corticospinal axon sprouting and regeneration in mice.<\/a><\/strong>
Geoffroy, C.G., Lorenzana, A.O., Kwan, J.P., Lin, K., Ghassemi, O., Ma, A., Xu, N., Greger, D., He, Z., and Zheng, B. J. Neurosci. 35, 6413-6428 (2015).<\/p>\n

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Neuron<\/h5>\n

Robust Axonal Regeneration Occurs in the Injured CAST\/Ei Mouse CNS.<\/a><\/strong>
\nOmura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ. Neuron 86, 1215-1227, 2015.<\/p>\n

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Nature Communications<\/h5>\n

Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3.<\/strong><\/a>
\nJin, D., Liu, Y., Sun, F., Wang X., Liu, X., and He, Z. Nature Commun. 2015 Nov 24;6:8074.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Neuron<\/h5>\n

Doublecortin-like kinases promote neuronal survival and induce growth cone reformation via<\/i> distinct mechanisms.<\/strong><\/a>
Nawabi, H., Belin, S., Cartoni, R., Williams, P.R., Wang, C., Latremoli\u00e8re, A., Wang, X., Fu, X., Zhu, J., Taub, D.G., Yu, B., Gu, X., Woolf, C.J., Liu, J.S., Gabel, C.V., Steen, J. A., and He, Z. Neuron 88, 704-719, 2015.<\/p>\n

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2014 Publications<\/h2>\n

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Exp Med<\/h5>\n

B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS.<\/strong><\/a>
\nO’Donovan KJ, Ma K, Guo H, Wang C, Sun F, Han SB, Kim H, Wong JK, Charron J, Zou H, Son YJ, He Z, Zhong J. J Exp Med. 211, 801-814, 2014.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Journal of Neuroscience<\/h5>\n

Characterization of long-descending pre-motor propriospinal neurons in the spinal cord.<\/strong><\/a>
Ni, Y, Nawabi, H., Liu, X., Yang, L., Miyamichi, K., Tedeschi, A., Xu, B., Wall, N. R., Callaway, E. M., and He, Z. J. Neurosci. 34, 9404-9417, 2014.<\/p>\n

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Cell Metabolism<\/h5>\n

Independent control of aging and axon regeneration.<\/strong><\/a>
\nBelin S, Norsworthy M, He Z. Cell Metabolism 19, 354-356, 2014. Review. [\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Current Opinion Neurobiology<\/h5>\n

Molecular mechanisms of intrinsic growth ability.<\/strong>
L. Lu and He, Z. Curr Opin Neurobiol 27C: 135-142, 2014. Review.<\/p>\n

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2013 Publications<\/h2>\n

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Journal of Neuroscience<\/h5>\n

Short hairpin RNA against PTEN enhances intrinsic growth of corticospinal tract axons after spinal cord injury.<\/strong>
Zukor, K., Belin, S., Wang, C., Keelan, N., Wang, X., and He, Z. J. Neurosci. 33, 15350-15261, 2013.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2012 Publications<\/h2>\n

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Neuron<\/h5>\n

Differential Effects of Unfolded Protein Response Pathways on Axon Injury-induced Death of Retinal Ganglion Cells.<\/strong>
\nHu, Y., Park, K.K., Yang, L., Wei, X., Yang, Q, Thielen, P., Lee, A-H., Cartoni, R., Glimcher, L. H., Chen, D.F., and He, Z. Neuron 73: 445-452, 2012.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Genes & Development<\/h5>\n

No simpler than mammals: axon and dendrite regeneration in Drosophila.<\/strong>
Nawabi, H, Zukor, K, and He, Z. Genes Dev. 26:1509-1514, 2012. Review.<\/p>\n

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2011 Publications<\/h2>\n

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Nature<\/h5>\n

Cortical representation of olfactory bulb input revealed by retrograde mono-transsynaptic labeling.<\/strong>
\nMiyamichi K, Amat F, Mousavi F, Wang C, Wickersham I, Wall N, Taniguchi H, Huang ZJ, He, Z., Callaway, E. M., Horowitz, M. A., and L. Luo. Nature 472, 191-196, 2011. [\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Nature<\/h5>\n

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3.<\/strong>
\nSun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z. Nature 2011 480, 372-375, 2011.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Annual Review of Neuroscience<\/h5>\n

Intrinsic controls of axon regeneration.<\/strong>
\nLiu K, Tedeschi K, Park, He Z. Ann Rev Neurosci 34, 131-152, 2011. Review. [\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Nature<\/h5>\n

Regenerative medicine: drawing breath after spinal injury.<\/strong>
\nZukor K, He Z. Nature 13;475:177-1778, 2011. Review. [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2010 Publications<\/h2>\n

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Nature Neuroscience<\/h5>\n

PTEN deletion enhances the regenerative ability of adult corticospinal neurons.<\/strong>
\nLiu K, Lu Y, Lee JK, Samara R, Willenberg R, Sears-Kraxberger I, Tedeschi A, Park KK, Jin D, Cai B, Xu B, Connolly L, Steward O, Zheng B, He Z. Nat Neurosci 2010:13(9):1075-1081.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2009 Publications<\/h2>\n

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Science<\/h5>\n

PTP{sigma} is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration.<\/strong>
\nShen Y, Tenney AP, Busch SA, Horn KP, Cuascut FX, Liu K, He Z, Silver J, Flanagan JG. Science 2009;326(5952):592-596. [\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Neuron<\/h5>\n

SOCS3 deletion promotes optic nerve regeneration in vivo.<\/strong>
\nSmith PD, Sun F, Park K, Cai B, Wang C, Kuwako K, Martinez-Carrasco I, Connolly L, He Z. Neuron 2009;64(5):617-623. [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2008 Publications<\/h2>\n

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Science<\/h5>\n

Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway.<\/strong>
\nPark K, Liu K, Hu Y, Smith P, Chen W, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z. Science 2008;322:963-966. [\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Molecular and Cellular Neuroscience<\/h5>\n

Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury.<\/strong>
\nJi B, Case LC, Liu K, Shao Z, Lee X, Yang Z, Wang J, Tian T, Shulga-Morskaya S, Scott M, He Z, Relton JK, Mi S. Mol Cell Neurosci 2008;39(2):258-267.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Journal of Biological Chemistry<\/h5>\n

The role of Kalirin9 in p75\/nogo receptor-mediated RhoA activation in cerebellar granule neurons.<\/strong>
Harrington AW, Li QM, Tep C, Park JB, He Z, Yoon SO. J Biol Chem 2008;283(36):24690-24697.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2007 Publications<\/h2>\n

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Journal of Neuroscience<\/h5>\n

The Nogo-66 receptor NgR1 is required only for the acute growth cone-collapsing but not the chronic growth-inhibitory actions of myelin inhibitors.<\/strong>
Chivatakarn O, Kaneko S, He Z, Tessier-Lavigne M, Giger RJ. J Neurosci 2007;27(27):7117-7124.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2006 Publications<\/h2>\n

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Journal of Neuroscience<\/h5>\n

Protecting Axonal Degeneration by Increasing NAD Levels in Experimental Autoimmune Encephalomyelitis Models.<\/strong>
Kaneko S, Wang J, Kaneko M, Yiu G, Hurrell J, Chitnis T, Khoury SJ, He Z. J Neurosci 2006;26(38):9794-9804.<\/p>\n

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Nature Reviews Neuroscience<\/h5>\n

Glial inhibition of CNS axon regeneration.<\/strong>
\nYiu G, He Z. Nature Rev Neurosci 2006;7:617-627. Review.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2005 Publications<\/h2>\n

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Neuron<\/h5>\n

A TNF receptor family member TROY is a co-receptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors.<\/strong>
\nPark J, Yiu G, Kaneko S, Wang J, Chang J, He Z. Neuron 2005;45:345-351.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Nature Neuroscience<\/h5>\n

LINGO-1 negatively regulates myelination by oligodendrocytes.<\/strong>
\nMi S, Miller RH, Lee X, Scott ML, Shulag-Morskaya S, Shao Z, Chang J, Thill G, Levesque M, Zhang M, Hession C, Sah D, Trapp B, He Z, Jung V, McCoy JM, Pepinsky RB. Nat Neurosci 2005;8:745-751.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Journal of Cell Biology<\/h5>\n

Mediation of NAD-dependent axon degeneration protection by a local mechanism.<\/strong>
Wang J, Zhai Q, Chen Y, He Z. J Cell Biol 2005;170(3):349-355.<\/p>\n

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Science<\/h5>\n

EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans.<\/strong>
\nKoprivica V, Cho KS, Park JB, Yiu G, Atwal J, Gore B, Kim JA, Lin E, Tessier-Lavigne M, Chen DF, He Z. Science 2005;310:106-110.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2004 Publications<\/h2>\n

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Journal of Neuroscience<\/h5>\n

Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state.<\/strong>
Fischer D, He Z, Benowitz LI. J Neurosci 2004;24:1646-1652.<\/p>\n

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Nature Neuroscience<\/h5>\n

PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration.<\/strong>
\nSivasankaran R, Pei J, Wang KC, Zhang YP, Shields CB, Xu X-M, He Z. Nature Neurosci 2004;7:261-268.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Annual Review Neuroscience<\/h5>\n

The Nogo Signaling Pathway for Regeneration Block.<\/strong>
\nHe Z, Koprivica V. Ann Review Neurosci 2004;27:341-368. Review. [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2003 Publications<\/h2>\n

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Neuron<\/h5>\n

Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration.<\/strong>
\nZhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z. Neuron 2003;39:217-225.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2002 Publications<\/h2>\n

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Nature<\/h5>\n

Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth.<\/strong>
\nWang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL, He Z. Nature 2002;417:941-944.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Neuron<\/h5>\n

Myelin-Associated Glycoprotein Interacts with the Nogo66 Receptor to Inhibit Neurite Outgrowth.<\/strong>
\nDomeniconi M, Cao Z, Spencer T, Sivasankaran R, Wang KC, Nikulina E, Kimura N, Cai H, Deng K, Gao Y, He Z, Filbin MT. Neuron 2002;35:283-290.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Nature<\/h5>\n

p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.<\/strong>
\nWang KC, Kim JA, Sivasankaran R, Segal R, He Z. Nature 2002;420:74-78.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Molecular and Cellular Neuroscience<\/h5>\n

Immunization with myelin or recombinant Nogo-66\/MAG in alum promotes axon regeneration and sprouting after corticospinal tract lesions in the spinal cord.<\/strong>
\nSicotte M, Tsatas O, Jeong SY, Cai CQ, He Z, David S. Mol Cell Neurosci 2002;23:251-263.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Neuron<\/h5>\n

Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition.<\/strong>
\nHe XL, Bazan JF, McDermott G, Park JB, Wang K, Tessier-Lavigne M, He Z, Garcia KC. Neuron 2002;38:177-185.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

2000 Publications<\/h2>\n

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PNAS<\/h5>\n

The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand dependent manner.<\/strong>
\nVikis HG, Li W, He Z, Guan K-L. PNAS 2000;97;12457-12462.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

1999 Publications<\/h2>\n

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Journal of Neurochemistry<\/h5>\n

Semaphorins as mediators of neuronal apoptosis.<\/strong>
\nShirvan A, Ziv I, Fleminger G, He Z, Brudo I, Melamed E, Barzilai A. J Neurochem 1999;73:961-971.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Cell<\/h5>\n

Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. <\/strong>
\nTamagnone L, Artigiani S, Chen H, He Z, Ming G-L, Song H-J, Chedotal A, Winberg ML, Goodman CS, Poo M-M, Tessier-Lavigne M, Comoglio PM. Cell 1999;99:71-80.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

1998 Publications<\/h2>\n

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Science<\/h5>\n

Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.<\/strong>
\nSong H-J, Ming G-L, He Z, Lehmann M, McKerracher L, Tessier-Lavigne M, Poo M-M. Science 1998;281:1515-1518.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Development<\/h5>\n

Semaphorins III and IV repel hippocampal axons via two distinct receptors.<\/strong>
\nChedotal A, Del Rio JA, Ruiz M, He Z, Borrell V, de Castro F, Ezan F, Goodman CS, Tessier-Lavigne M, Sotelo C, Soriano E. Development 1998;125:4313-4323.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Neuron<\/h5>\n

Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins.<\/strong>
\nChen H, He Z, Bagri A, Tessier-Lavigne M. Neuron 1998;21:1283-1290.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

1997 Publications<\/h2>\n

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Cell<\/h5>\n

Neuropilin is a receptor for the axonal chemorepellent Semaphorin III.<\/strong>
\nHe Z, Tessier-Lavigne M. Cell 1997;90(4): 739-751.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Neuron<\/h5>\n

Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III.<\/strong>
\nChen H, Chedotal A, He Z, Goodman CS, Tessier-Lavigne M. Neuron 1997;19(3), 547-559.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Nucleic Acids Research<\/h5>\n

Isolation of human complexes proficient in nucleotide excision repair.<\/strong>
\nHe Z, Ingles CJ. Nucleic Acids Res 1997;25(6):1136-1141.[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Biochemistry<\/h5>\n

Role of protein-protein interactions in the function of replication protein A (RPA): RPA modulates the activity of DNA polymerase a by multiple mechanisms.<\/strong>
\nBraun KA, Lao Y, He Z, Ingles CJ, Wold MS. Biochemistry 1997;36(28):8443-8454.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

1996 Publications<\/h2>\n

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Journal of Biological Chemistry<\/h5>\n

Yeast replication protein A (RPA) is required for nucleotide excision repair in vitro.<\/strong>
\nHe Z, Wong JMS, Maniar HS, Brill SJ, and Ingles CJ. J Biol Chem 1996;271(45):28243-28249.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

1995 Publications<\/h2>\n

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Nature<\/h5>\n

RPA involvement in the damage-recognition and incision steps of nucleotide excision repair.<\/strong>
\nHe Z, Henricksen LA, Wold MS, and Ingles CJ. Nature 1995;374(6522):566-569.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

1994 Publications<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Genomics<\/h5>\n

The structure of the human sterol carrier protein X\/sterol carrier protein 2 gene (SCP2).<\/strong>
\nOhba T, Rennert H, Pfeifer SM, He Z, Yamamoto R, Holt JA, Billheimer JT, Strauss III JF. Genomics 1994;24(2):370-374.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

1993 Publications<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

Cell<\/h5>\n

The transactivator proteins VP16 and GAL4 bind replication factor A.<\/a><\/strong>
\nHe Z, Brinton BT, Greenblatt J, Hassell JA, Ingles CJ. Cell 1993;73(6):1223-1232.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_text_color=”#e02b20″ header_2_text_color=”#01b5cf” global_colors_info=”{}”]<\/p>\n

1991 Publications<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_padding=”||30px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n

DNA Cell Biology<\/h5>\n

cDNAs encoding members of a family of proteins related to human sterol carrier protein 2 and assignment of the gene to human chromosome 1 p21—-pter.<\/strong><\/a>
He Z, Yamamoto R, Furth EE, Schantz LJ, Naylor SL, George H, Billheimer JT, Strauss JF 3rd. DNA Cell Biol. 1991 Oct;10(8):559-69. doi: 10.1089\/dna.1991.10.559. PMID: 1718316<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

The Zhigang He Laboratory at the FM Kirby Neurobiology CenterLab Publications2025 PublicationsCell Reports From thought to action: The organization of spinal projecting neurons Winter CC, Wang KH, He Z. Cell Rep. 2025 Aug 14;44(8):116153. doi: 10.1016\/j.celrep.2025.116153. Epub ahead of print. PMID: 40818073. Download Paper Cell Repeat-element RNAs integrate a neuronal growth circuit Zahavi EE, Koppel […]<\/p>\n","protected":false},"author":12,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-57","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/kirbyneuro.org\/ZhigangHe\/wp-json\/wp\/v2\/pages\/57","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kirbyneuro.org\/ZhigangHe\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kirbyneuro.org\/ZhigangHe\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kirbyneuro.org\/ZhigangHe\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/kirbyneuro.org\/ZhigangHe\/wp-json\/wp\/v2\/comments?post=57"}],"version-history":[{"count":177,"href":"https:\/\/kirbyneuro.org\/ZhigangHe\/wp-json\/wp\/v2\/pages\/57\/revisions"}],"predecessor-version":[{"id":5563,"href":"https:\/\/kirbyneuro.org\/ZhigangHe\/wp-json\/wp\/v2\/pages\/57\/revisions\/5563"}],"wp:attachment":[{"href":"https:\/\/kirbyneuro.org\/ZhigangHe\/wp-json\/wp\/v2\/media?parent=57"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}