{"id":895,"date":"2019-02-21T23:07:29","date_gmt":"2019-02-21T23:07:29","guid":{"rendered":"https:\/\/kirbyneuro.org\/XinTangLab\/?page_id=895"},"modified":"2021-11-30T21:26:02","modified_gmt":"2021-11-30T21:26:02","slug":"fundamental-science","status":"publish","type":"page","link":"https:\/\/kirbyneuro.org\/XinTangLab\/fundamental-science\/","title":{"rendered":"Fundamental Science"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”BKGD IMAGE” _builder_version=”4.10.7″ background_enable_color=”off” background_enable_image=”off” background_size=”contain” custom_margin=”10px||||false|false” custom_padding=”0px||0px||false|false” global_module=”4604″ saved_tabs=”all” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.10.6″ background_enable_color=”off” background_enable_image=”off” module_alignment=”center” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.10.6″ custom_padding=”||||false|false” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/kirbyneuro.org\/XinTangLab\/wp-content\/uploads\/2021\/09\/logo-tang-v8-master.jpg” title_text=”logo-tang-v6-master” url=”https:\/\/kirbyneuro.org\/XinTangLab\/” show_bottom_space=”off” _builder_version=”4.10.7″ _module_preset=”default” custom_margin=”10px||10px||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.11.2″ _module_preset=”default” background_color=”#84cbdd” background_image=”https:\/\/kirbyneuro.org\/XinTangLab\/wp-content\/uploads\/2021\/09\/tang-dna-divider-v3.png” background_size=”initial” background_repeat=”repeat-x” height=”75px” max_height=”75px” custom_margin=”20px||0px||false|false” custom_padding=”0px||0px||false|false” box_shadow_style=”preset6″ box_shadow_color=”rgba(0,0,0,0.5)” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.11.2″ _module_preset=”default” height=”75px” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.11.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.11.2″ background_color=”RGBA(0,0,0,0)” custom_margin=”30px||||false|false” custom_padding=”0|0px|0|0|false|false” box_shadow_style=”preset6″ box_shadow_color=”RGBA(0,0,0,0)” global_colors_info=”{}”][et_pb_row _builder_version=”4.10.8″ custom_padding=”0px|0px|50px|0px|false|false” border_color_bottom=”#29aae1″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.11.2″ _module_preset=”default” custom_margin=”0px||29px||false|false” custom_padding=”0px||||false|false” global_colors_info=”{}”]<\/p>\n

Fundamental Science<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.11.2″ text_font_size=”18px” text_line_height=”1.6em” global_colors_info=”{}”]<\/p>\n

Our lab is dedicated to advancing precision medicine for brain disorders using genome-edited human stem cells. We leverage cutting-edge technologies including CRISPR gene editing, human stem cells, single-cell RNA sequencing, and organoid culture, to create physiologically-relevant models of human brain diseases for mechanistic investigation. Along the same line, we also develop high-throughput drug\/gene discovery platforms to identify small molecule or nucleic acid therapeutics that regulate the expression of disease risk genes to treat or even cure devastating brain diseases such as neurodevelopmental disorders, epilepsy, and brain tumor.<\/p>\n

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Research Direction 1:<\/h4>\n

Reverse neurodevelopmental disorders<\/h3>\n

[\/et_pb_text][et_pb_text _builder_version=”4.14.1″ _module_preset=”default” custom_margin=”||28px|||” global_colors_info=”{}”]<\/p>\n

We aim to generate a systematic understanding of the gene expression alterations induced by brain disease risk genes mutations or precision medicine drug treatment. Our long term goal is to leverage such insights to match brain disease patients to targeted therapies they may benefit from.<\/a><\/p>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/kirbyneuro.org\/XinTangLab\/reverse-neurodevelopmental-disorders\/” button_text=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rIiwic2V0dGluZ3MiOnsiYmVmb3JlIjoiIiwiYWZ0ZXIiOiIiLCJ0ZXh0IjoiY3VzdG9tIiwiY3VzdG9tX3RleHQiOiJMRUFSTiBNT1JFICZndDsifX0=@” button_alignment=”right” admin_label=”JOIN US BUTTON” _builder_version=”4.14.1″ _dynamic_attributes=”button_text” _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#29aae1″ button_bg_color=”RGBA(0,0,0,0)” button_border_width=”1px” button_border_color=”#29aae1″ button_border_radius=”5px” button_letter_spacing=”0px” button_use_icon=”off” custom_padding=”|20px||25px|false|false” locked=”off” global_colors_info=”{}” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#29aae1″ button_bg_enable_color__hover=”on” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.14.1″ _module_preset=”default” custom_padding=”|0px|50px|0px|false|false” border_width_bottom=”1px” border_color_bottom=”#29aae1″ global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.10.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/kirbyneuro.org\/XinTangLab\/wp-content\/uploads\/2021\/11\/Tang-FScience-Project02.jpg” alt=”FLT3 Kinase Signaling in the Brain” title_text=”Tang-FScience-Project02″ align=”center” _builder_version=”4.14.1″ _module_preset=”default” height=”250px” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.10.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.1″ _module_preset=”default” header_4_font=”|||on|||||” header_4_text_color=”#FFFFFF” background_color=”#84cbdd” custom_margin=”||||false|false” custom_padding=”20px|20px|20px|20px|false|false” global_colors_info=”{}”]<\/p>\n

Research Direction 2:<\/h4>\n

Role of FLT3 Signaling in the Brain<\/h3>\n

[\/et_pb_text][et_pb_text _builder_version=”4.14.1″ custom_margin=”||29px|||” global_colors_info=”{}”]Our previous unbiased drug screening discovered the unexpected roles of FLT3 kinase in synapse development and neuroinflammation. We will further elucidate the molecular and cellular basis of FLT3 signaling in the brain.[\/et_pb_text][et_pb_button button_url=”https:\/\/kirbyneuro.org\/XinTangLab\/flt3-signaling-in-the-brain\/” button_text=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rIiwic2V0dGluZ3MiOnsiYmVmb3JlIjoiIiwiYWZ0ZXIiOiIiLCJ0ZXh0IjoiY3VzdG9tIiwiY3VzdG9tX3RleHQiOiJMRUFSTiBNT1JFICZndDsifX0=@” button_alignment=”right” admin_label=”JOIN US BUTTON” _builder_version=”4.14.1″ _dynamic_attributes=”button_text” _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#29aae1″ button_bg_color=”RGBA(0,0,0,0)” button_border_width=”1px” button_border_color=”#29aae1″ button_border_radius=”5px” button_letter_spacing=”0px” button_use_icon=”off” custom_padding=”|20px||25px|false|false” locked=”off” global_colors_info=”{}” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#29aae1″ button_bg_enable_color__hover=”on” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.14.1″ _module_preset=”default” custom_padding=”|0px|50px|0px|false|false” border_width_bottom=”1px” border_color_bottom=”#29aae1″ global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.10.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/kirbyneuro.org\/XinTangLab\/wp-content\/uploads\/2021\/11\/Tang-FScience-Project03.jpg” alt=”Tumor Growth from within the Organoid” title_text=”Tang-FScience-Project03″ align=”center” _builder_version=”4.14.1″ _module_preset=”default” height=”250px” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.10.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.1″ _module_preset=”default” header_4_font=”|||on|||||” header_4_text_color=”#FFFFFF” background_color=”#84cbdd” custom_margin=”||||false|false” custom_padding=”20px|20px|20px|20px|false|false” global_colors_info=”{}”]<\/p>\n

Research Direction 3:<\/h4>\n

Organoid Models of Brain Tumor<\/h3>\n

[\/et_pb_text][et_pb_text _builder_version=”4.14.1″ _module_preset=”default” custom_margin=”||30px|||” global_colors_info=”{}”]We strive to create 3D human organoid models of brain tumor in order to recapitulate and manipulate the molecular and cellular events during brain cancer initiation, progression, and elimination.[\/et_pb_text][et_pb_button button_url=”https:\/\/kirbyneuro.org\/XinTangLab\/organoid-models-of-brain-tumor” button_text=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rIiwic2V0dGluZ3MiOnsiYmVmb3JlIjoiIiwiYWZ0ZXIiOiIiLCJ0ZXh0IjoiY3VzdG9tIiwiY3VzdG9tX3RleHQiOiJMRUFSTiBNT1JFICZndDsifX0=@” button_alignment=”right” admin_label=”JOIN US BUTTON” _builder_version=”4.14.1″ _dynamic_attributes=”button_text” _module_preset=”default” custom_button=”on” button_text_size=”14px” button_text_color=”#29aae1″ button_bg_color=”RGBA(0,0,0,0)” button_border_width=”1px” button_border_color=”#29aae1″ button_border_radius=”5px” button_letter_spacing=”0px” button_use_icon=”off” custom_padding=”|20px||25px|false|false” locked=”off” global_colors_info=”{}” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#29aae1″ button_bg_enable_color__hover=”on” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#FFFFFF”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Fundamental ScienceOur lab is dedicated to advancing precision medicine for brain disorders using genome-edited human stem cells. We leverage cutting-edge technologies including CRISPR gene editing, human stem cells, single-cell RNA sequencing, and organoid culture, to create physiologically-relevant models of human brain diseases for mechanistic investigation. Along the same line, we also develop high-throughput drug\/gene discovery […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-895","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/kirbyneuro.org\/XinTangLab\/wp-json\/wp\/v2\/pages\/895","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kirbyneuro.org\/XinTangLab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kirbyneuro.org\/XinTangLab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kirbyneuro.org\/XinTangLab\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/kirbyneuro.org\/XinTangLab\/wp-json\/wp\/v2\/comments?post=895"}],"version-history":[{"count":58,"href":"https:\/\/kirbyneuro.org\/XinTangLab\/wp-json\/wp\/v2\/pages\/895\/revisions"}],"predecessor-version":[{"id":4950,"href":"https:\/\/kirbyneuro.org\/XinTangLab\/wp-json\/wp\/v2\/pages\/895\/revisions\/4950"}],"wp:attachment":[{"href":"https:\/\/kirbyneuro.org\/XinTangLab\/wp-json\/wp\/v2\/media?parent=895"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}