[et_pb_section fb_built=”1″ admin_label=”BKGD IMAGE” _builder_version=”4.10.7″ background_enable_color=”off” background_enable_image=”off” background_size=”contain” custom_margin=”10px||||false|false” custom_padding=”0px||0px||false|false” global_module=”4604″ saved_tabs=”all” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_enable_color=”off” background_enable_image=”off” module_alignment=”center” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”||||false|false” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/kirbyneuro.org\/XinTangLab\/wp-content\/uploads\/2021\/09\/logo-tang-v8-master.jpg” title_text=”logo-tang-v6-master” url=”https:\/\/kirbyneuro.org\/XinTangLab\/” show_bottom_space=”off” _builder_version=”4.16″ _module_preset=”default” custom_margin=”10px||10px||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#c1d66d” background_image=”https:\/\/kirbyneuro.org\/XinTangLab\/wp-content\/uploads\/2021\/09\/tang-neuron-divider-v2.png” background_size=”initial” background_repeat=”repeat-x” height=”75px” max_height=”75px” custom_margin=”20px||0px||false|false” custom_padding=”0px||0px||false|false” box_shadow_style=”preset6″ box_shadow_color=”rgba(0,0,0,0.4)” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” height=”75px” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ background_color=”RGBA(0,0,0,0)” custom_margin=”29px||||false|false” custom_padding=”0|0px|0|0|false|false” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_color=”RGBA(0,0,0,0)” custom_padding=”0px|0px|50px|0px|false|false” border_color_bottom=”#29aae1″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||30px||false|false” custom_padding=”0px||||false|false” global_colors_info=”{}”]<\/p>\n
Translational Science<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font_size=”18px” text_line_height=”1.6em” global_colors_info=”{}”]<\/p>\n
The translation of research findings into therapies and cures is the ultimate goal of our work. Our lab is actively engaged in the Boston Children\u2019s Hospital environment, which integrates bench research, patient care and medical education. This is the ideal context in which basic biological findings, emerging technologies and best-in-class clinical services lead to clinically-applicable solutions for the diagnosis and treatment of brain disorders.\u00a0<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_margin=”18px||0px||false|false” custom_padding=”0px||0px||false|false” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” background_color=”#f4981f” custom_margin=”0px||0px||false|false” custom_padding=”|||35px|false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_4_font=”|||on|||||” header_4_text_color=”#FFFFFF” custom_margin=”10px||10px||false|false” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ background_enable_color=”off” custom_margin=”35px||||false|false” custom_padding=”0|0px|0|0|false|false” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_padding=”0px|0px|1px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ custom_margin=”||-3px|||” global_colors_info=”{}”]<\/p>\n
E<\/span>very step of the way, our approach to translational research is informed by our collaborations with clinical experts to identify significant unmet needs. We apply our expertise in mechanistic research and technology development to devise customized methodologies, and continue our engagement with clinicians through an iterative process of optimization of the prototype technologies to facilitate their clinical translation.<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ custom_margin=”||-3px|||” global_colors_info=”{}”]<\/p>\n <\/p>\n Examples of translational work<\/strong>:<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ custom_margin=”||-3px|||” global_colors_info=”{}”]<\/p>\n 1<\/span>Injectable drug and nucleic acid formulations that temporarily silence brain regions, mimicking tissue ablation in order to improve the safety and efficacy of surgical interventions.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ custom_margin=”||-3px|||” global_colors_info=”{}”]<\/p>\n 2<\/span> Surgically-resected brain tumor tissue samples to dissect and reconstruct brain cancer microenvironments.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ custom_margin=”||-3px|||” global_colors_info=”{}”]<\/p>\n 3<\/span>Genetic models of vascular disorders of the brain.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ custom_padding=”0px|0px|0px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|0px|||false|false” custom_padding_tablet=”|0px|||false|false” custom_padding_phone=”|0px|||false|false” custom_padding_last_edited=”on|desktop” border_width_right=”3px” border_color_right=”#c4c4c4″ border_width_right_tablet=”0px” border_width_right_phone=”0px” border_width_right_last_edited=”on|desktop” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/kirbyneuro.org\/XinTangLab\/wp-content\/uploads\/2021\/09\/Tang-TResearch-BrainInjectionSurgery-1080.jpg” title_text=”Tang-TResearch-BrainInjectionSurgery-1080″ show_bottom_space=”off” align=”center” _builder_version=”4.16″ custom_margin=”||||false|false” custom_padding=”|30px|||false|false” custom_padding_tablet=”|0px|||false|false” custom_padding_phone=”|0px|||false|false” custom_padding_last_edited=”on|desktop” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”||on||||||” text_font_size=”12px” custom_margin=”-3px|||||” custom_padding=”0px||” global_colors_info=”{}”]<\/p>\n Test drive neurosurgery through injectable agents<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/kirbyneuro.org\/XinTangLab\/wp-content\/uploads\/2021\/11\/IronMatt-figure-1-1080.jpg” alt=”Generation of brain tumor fusion organoids” title_text=”IronMatt-figure-1-1080″ _builder_version=”4.16″ _module_preset=”default” custom_margin=”42px||||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”||on||||||” text_font_size=”12px” custom_margin=”-3px|||||” custom_padding=”0px||” global_colors_info=”{}”]<\/p>\n Generation of human brain\/tumor fusion organoids<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ custom_margin=”||22px|||” custom_padding=”0px|||||” global_colors_info=”{}”]<\/p>\n T<\/span>o foster a culture of collaboration between researchers and clinicians in the Department of Neurosurgery at BCH and beyond, Dr. Tang and Dr. Joseph Madsen of BCH Department of Neurosurgery co-host a monthly Neurosurgery Translational Research Roundtable Series, which brings together translational research communities. Please contact Dr. Tang<\/a> if you are interested in participating in the series.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.3″ _module_preset=”default” custom_margin=”|auto|75px|auto||” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.3″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n Clinical collaborators:<\/strong> Joseph Madsen<\/a>, Lissa Baird<\/a>, Mariella Filbin<\/a><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Translational ScienceThe translation of research findings into therapies and cures is the ultimate goal of our work. Our lab is actively engaged in the Boston Children\u2019s Hospital environment, which integrates bench research, patient care and medical education. 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