[et_pb_section fb_built=”1″ _builder_version=”4.27.3″ background_color=”#000000″ custom_padding=”0|0px|0|0px|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_padding=”0px||6px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2024\/12\/IMG_4004-edit-1-scaled.jpg” title_text=”IMG_4004 edit” show_bottom_space=”off” force_fullwidth=”on” _builder_version=”4.27.3″ global_colors_info=”{}”][\/et_pb_image][et_pb_text module_id=”director” _builder_version=”4.27.3″ min_height=”46px” custom_margin=”||-7px|||” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”0|0px|0|0|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_padding=”50px|0px|0|0px|false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.21.0″ text_font=”|800|||||||” text_font_size=”30px” header_font=”|800|||||||” global_colors_info=”{}”]<\/p>\n
Principal Investigator<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2019\/06\/PoduriA_Website_01.jpg” title_text=”PoduriA_Website_01″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.21.0″ _module_preset=”default” text_font_size=”12px” custom_margin=”-30px||||false|false” global_colors_info=”{}”]<\/p>\n
Photo by Anna Oliveira<\/em><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.21.0″ _module_preset=”default” text_font=”|800|||||||” text_font_size=”21px” text_line_height=”1.8em” custom_margin=”||9px||false|false” global_colors_info=”{}”]<\/p>\n Annapurna (Ann) Poduri, MD, MPH<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_font=”|700|||||||” text_text_color=”#000000″ text_font_size=”17px” global_colors_info=”{}”]<\/p>\n Director, Epilepsy Genetics Program, Boston Children’s Hospital<\/p>\n Co-Director, Program in Neurogenetics, Boston Children’s Hospital<\/p>\n Professor of Neurology, Harvard Medical School<\/p>\n Diamond Blackfan Chair of Neuroscience Research, Boston Children’s Hospital<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ min_height=”306px” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.21.0″ custom_margin=”-30px||-20px||false|false” global_colors_info=”{}”]<\/p>\n Ann directs the Epilepsy Genetics Program at Boston Children’s Hospital as a clinician-scientist, with one hand in the clinic as a pediatric epileptologist and the other hand in the laboratory on a mission to identify the genetic underpinnings of epilepsy. She is a Professor of Neurology at Harvard Medical School, and she is the Diamond Blackfan Chair of Neuroscience Research and the Co-Director of the Neurology Department’s Program in Neurogenetics at Boston Children\u2019s.<\/p>\n Ann received her BA in Biology summa cum laude from Harvard University, her MD from the University of Pennsylvania School of Medicine, and her MPH from the Harvard School of Public Health. She completed pediatric training at Boston Children\u2019s Hospital, child neurology residency at the Children\u2019s Hospital of Philadelphia, and clinical neurophysiology fellowship at Boston Children\u2019s Hospital. It was through her rich clinical training that she developed research hypotheses that she pursued as a post-doctoral fellow in the laboratory of Christopher A. Walsh, where she received rich training and mentorship in dominant and recessive neurogenetics and pioneered the study of mosaic (post-zygotic) mutation in developmental brain disorders that lead to epilepsy. Ann started the Epilepsy Genetics Program at Boston Children’s in 2011 to create a translational infrastructure for clinical and research activities focused on epilepsy genetics. She started her independent research laboratory at Boston Children\u2019s Hospital in 2013, integrating clinical research with bench laboratory research focusing primarily on the zebrafish model system.<\/p>\n Ann is a key participant in epilepsy genetics research at the local, national, and international level. She has been part of an international effort to understand the genetics of severe early-onset epilepsies; she served as the Boston Children’s Investigator for the NIH-funded Epilepsy Phenome\/Genome Project (EPGP), a national, multi-centered research study, and Co-Investigator for the Epi4K follow-up study. She serves on the International League Against Epilepsy Genetics Commission and chairs the American Epilepsy Society\/National Institute of Neurological Disorders and Stroke (NINDS) Benchmarks Stewards Committee.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ min_height=”49px” custom_padding=”25.2656px|0px|0px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider _builder_version=”4.16″ height=”2px” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”0|0px|0|0px|false|false” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text module_class=”people_button” _builder_version=”4.27.6″ text_font=”||||||||” link_font=”||||||||” text_orientation=”center” custom_margin=”||0px||false|false” hover_enabled=”0″ global_colors_info=”{}” link_text_color__hover=”#e02b20″ sticky_enabled=”0″]<\/p>\n <\/a>Chris McGraw, MD, PhD<\/a> |\u00a0Anna Duncan, MD, MHS<\/a> | Alissa D’Gama, MD, PhD<\/a> | Sneham Tiwari, PhD<\/a> | Marshall Lukacs, MD, PhD<\/a> | Dustin Gable, MD, PhD<\/a> | Joseph Pascucci<\/a> | Mark LaCoursiere, MS<\/a> | Parul Chaudhary, MBBS, PhD<\/a><\/a><\/a><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.21.0″ custom_margin=”-100px||||false|false” custom_padding=”30px|0px|0|0px|false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.21.0″ _module_preset=”default” custom_margin=”-60px||-30px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.21.0″ _module_preset=”default” text_font=”|800|||||||” text_font_size=”30px” global_colors_info=”{}”]<\/p>\n Postdoctoral Fellows<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Chris McGraw, MD, PhD” position=”Research Associate” image_url=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2019\/06\/McGraw-Chris-headshot_2018-e1561469929131.jpg” module_id=”chrism” _builder_version=”4.21.0″ _module_preset=”default” header_level=”h3″ header_font=”|800|||||||” header_font_size=”20px” body_font_size=”12px” body_line_height=”1.5em” position_font=”|700|||||||” position_text_align=”left” position_text_color=”#000000″ position_font_size=”18px” position_line_height=”1.5em” global_colors_info=”{}”]<\/p>\n Chris joined the Poduri Laboratory and Epilepsy Genetics Program in July 2018. He is a physician-scientist with interests spanning epilepsy and clinical neurophysiology who makes use of diverse animal models as well as human data to improve our tools for treating seizure disorders. Chris received his BA in Biochemistry and Cell Biology at Rice University in 2004 and he completed a combined MD\/PhD program at Baylor College of Medicine, earning a PhD in Developmental Biology under Dr. Huda Y. Zoghbi MD in 2012 before graduating in 2014. He attended residency in Adult Neurology at University of California San Francisco (UCSF), where he was awarded an R25 supplement to study epilepsy in zebrafish with Dr. Scott Baraban PhD. He is currently a fellow in Epilepsy at Massachusetts General Hospital (MGH) in addition to continuing basic science research in zebrafish through the Epilepsy Genetics Program at Boston Children’s Hospital. Chris is interested in developing novel models of epilepsy in zebrafish with high translational potential, with a special interest in high-throughput whole organism screening strategies using zebrafish.<\/p>\n Harvard Catalyst Profile ><\/a><\/p>\n [\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Anna Duncan, MD, MHS” position=”Attending Neonatologist at MGH and Research fellow” image_url=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2024\/12\/ADuncan_photo-1.jpg” module_id=”anna” _builder_version=”4.27.3″ _module_preset=”default” header_level=”h3″ header_font=”|800|||||||” header_font_size=”20px” body_font_size=”12px” body_line_height=”1.5em” position_font=”|700|||||||” position_text_align=”left” position_text_color=”#000000″ position_font_size=”18px” position_line_height=”1.5em” global_colors_info=”{}”]<\/p>\n Harvard Catalyst Profile ><\/a><\/p>\n [\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Alissa D’Gama, MD, PhD” position=”Attending Physician, Research Fellow” image_url=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2024\/09\/DGama_AlissaSM.jpg” module_id=”alissa” _builder_version=”4.25.1″ _module_preset=”default” header_level=”h3″ header_font=”|800|||||||” header_font_size=”20px” body_font_size=”12px” body_line_height=”1.5em” position_font=”|700|||||||” position_text_align=”left” position_text_color=”#000000″ position_font_size=”18px” position_line_height=”1.5em” global_colors_info=”{}”]<\/p>\n Alissa joined the Poduri Laboratory and Epilepsy Genetics Program in 2021. She is a physician scientist with interests spanning neonatology, developmental neuroscience, and genetics and genomics. She received her BA in Molecular and Cellular Biology from Harvard College in 2011 and completed a combined MD-PhD program at Harvard\/MIT, receiving a PhD in Biological and Biomedical Sciences under Dr. Christopher A. Walsh from Harvard Medical School in 2016 and a MD from Harvard Medical School\/MIT Health Sciences and Technology in 2018. She completed pediatrics residency training in the Boston Combined Residency Program on the Accelerated Research Pathway and neonatal-perinatal fellowship in the Harvard Neonatal-Perinatal Medicine Program, where she served as Chief Fellow. Alissa is currently an attending neonatologist at Boston Children’s Hospital and her research focuses on advancing equitable precision medicine for infants with epilepsy and related neurogenetic disorders. She is co-mentored by Dr. Timothy Yu.\u00a0<\/span><\/p>\n Harvard Catalyst Profile ><\/a><\/p>\n [\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Sneham Tiwari, PhD” position=”Research Fellow” image_url=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2024\/08\/IMG_4421.jpeg” module_id=”sneham” _builder_version=”4.25.1″ _module_preset=”default” header_level=”h3″ header_font=”|800|||||||” header_font_size=”20px” body_font_size=”12px” body_line_height=”1.5em” position_font=”|700|||||||” position_text_align=”left” position_text_color=”#000000″ position_font_size=”18px” position_line_height=”1.5em” global_colors_info=”{}”]<\/p>\n Sneham joined the Poduri Laboratory and Epilepsy Genetics Program in February 2023. She recently received her Ph.D. in Biomedical sciences from Herbert Wertheim College of Medicine at Florida International University. With her background in neuroscience and molecular biology, she is interested in understanding the neurological disorders and factors involved in the abnormal functioning of the brain. Here in the Poduri Lab, she is pursuing her passion and studying epilepsy genetics with an emphasis on cellular mosaicism. She focuses on studying the somatic mutations occurring in genes of the mTOR pathway, targeting important genes that affect brain development. Sneham is interested in developing novel epilepsy zebrafish models, utilizing these models with high translational potential in deciphering mechanisms underlying neurological disorders, and translating towards high throughput drug screening and targeted efficient bioavailable therapeutics development to enhance patients\u2019 quality of life.<\/p>\n Google Scholar profile ><\/a><\/p>\n [\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Marshall Lukacs, MD, PhD” position=”Research Fellow” image_url=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2022\/11\/Picture1-e1691508504533.jpg” module_id=”marshall” _builder_version=”4.21.0″ _module_preset=”default” header_level=”h3″ header_font=”|800|||||||” header_font_size=”20px” body_font_size=”12px” body_line_height=”1.5em” position_font=”|700|||||||” position_text_align=”left” position_text_color=”#000000″ position_font_size=”18px” position_line_height=”1.5em” global_colors_info=”{}”]<\/p>\n Coming soon…<\/p>\nLab Member Links<\/strong><\/h4>\n