{"id":2,"date":"2019-01-28T21:32:55","date_gmt":"2019-01-28T21:32:55","guid":{"rendered":"https:\/\/kirbyneuro.org\/PoduriLab\/?page_id=2"},"modified":"2026-03-24T17:35:27","modified_gmt":"2026-03-24T17:35:27","slug":"home-page","status":"publish","type":"page","link":"https:\/\/kirbyneuro.org\/PoduriLab\/","title":{"rendered":"Home"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”BKGD IMAGE” _builder_version=”4.16″ background_color=”#000000″ custom_margin=”||||false|false” custom_padding=”0px||1px||false|false” global_colors_info=”{}”][et_pb_row custom_padding_last_edited=”off|desktop” _builder_version=”4.16″ background_enable_color=”off” background_enable_image=”off” background_position=”top_left” height_tablet=”” height_phone=”” height_last_edited=”on|desktop” custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2020\/02\/Home-and-Research-Page-header-v1.jpg” title_text=”Home and Research Page header v1″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ background_color=”#000000″ custom_padding=”0|0px|100px|0px|false|false” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.16″ custom_padding=”0|0px|0|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ min_height=”50px” custom_margin=”-20px||||false|false” custom_padding=”0px||” global_colors_info=”{}”]<\/p>\n

Transgenic zebrafish brain with inhibitory and excitatory neurons labelled green and red, respectively<\/span><\/h6>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_padding=”0px|0px|0px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Text” _builder_version=”4.16″ text_font=”Trebuchet||||||||” header_font=”||||||||” header_2_font=”||||||||” header_3_font=”||||||||” background_size=”initial” background_position=”top_left” background_repeat=”repeat” min_height=”320px” custom_padding=”0px|||||” global_colors_info=”{}”]<\/p>\n

Welcome to the Poduri Lab!<\/div>\n

 <\/p>\n

The Poduri Laboratory was launched in 2013 within the Department of Neurology and F.M. Kirby Neurobiology Center at Boston Children\u2019s Hospital. Our translational Epilepsy Genetics Program encompasses human genetics research in epilepsy in parallel with bench laboratory research on genetic epilepsies.<\/span><\/p>\n

Our ongoing gene discovery efforts and genotype-phenotype research inform our genetic epilepsy models. Our lab uses the zebrafish model system to study known and candidate epilepsy\u00a0genes. We utilize transgenic zebrafish as functional models of seizures and related neurodevelopmental phenotypes. With bidirectional feedback between our clinical research team and bench laboratory research team, we are establishing a sustainable paradigm for high-throughput translational research in genetic epilepsy, with the ultimate goal of a targeted, \u201cprecision medicine\u201d approach to the treatment of epilepsy in all patients. To that end, we are interested in evaluating models across several platforms, and we are collaborating with other laboratories to pursue models of some key epilepsy-related genes in mouse and in iPSC-derived neurons.\u00a0<\/span><\/p>\n

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[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_slider _builder_version=”4.27.6″ header_font=”|600|||||||” header_text_color=”#e0b14c” header_font_size=”20px” body_font=”||||||||” background_color=”#000000″ min_height=”466px” auto=”on” auto_speed=”5000″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_slide heading=” Congratulations to Alissa D’ Gama and Anna Duncan for receiving prestigious HMS career development grants (December 2024)” button_text=”Click Here” image=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2024\/12\/IMG_3826-scaled.jpg” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

Anna Duncan has been awarded the Eleanor and Miles Shore Faculty Development Award from the Department of Pediatrics at Massachusetts General Hospital. Her project, “Understanding the Impact of EIF4A2 Variants on Zebrafish Interneuron Development,”<\/em>.<\/p>\n

Alissa D’ Gama has been awarded the Boston Children’s Hospital OFD\/BTREC\/CTREC Faculty Career Development Fellowship for her groundbreaking project, “Comprehensive Genomic Sequencing to Delineate the Molecular Genetic Landscape of Pediatric Epilepsy.”<\/em><\/p>\n

These prestigious grants reflect Alissa and Anna’s exceptional dedication and the immense potential of their transformative research. We are incredibly proud of their accomplishments and excited to see the impact they will make in the field!<\/p>\n

[\/et_pb_slide][et_pb_slide heading=”Annapurna Poduri, MD, MPH appointed as NINDS Deputy Director (September 2024)” button_text=”Click Here” button_link=”https:\/\/www.ninds.nih.gov\/news-events\/news\/highlights-announcements\/annapurna-poduri-md-mph-appointed-ninds-deputy-director” image=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2019\/11\/Epilepsy-Quotes-Poduri.jpg” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

Dr. Poduri is currently Director of the Epilepsy Genetics and Neurogenetics Programs, Associate Chief for Academic Development in the Department of Neurology, and the Diamond Blackfan Chair of Neuroscience Research at Boston Children\u2019s Hospital. Dr. Poduri will join NINDS as the Deputy Director at the end of September. Dr. Poduri will continue her experimental science work within the intramural program of the\u00a0<\/span>Eunice Kennedy Shriver<\/em>\u00a0National Institute of Child Health and Human Development.\u00a0<\/span><\/p>\n

[\/et_pb_slide][et_pb_slide heading=”Congratulations, Alissa, for winning two of the prestigious awards (April 2024 and August 2024)” button_text=”Click Here” button_link=”https:\/\/www.childrenshospital.org\/research\/office-faculty-development\/fellowships-opportunities” image=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2024\/09\/DGama_AlissaSM.jpg” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

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  1. Boston Children’s Hospital Office of Faculty Development\/Basic & Clinical Translational Research Executive Committees Faculty Career Development Fellowship, awarded April 2024\u00a0<\/span><\/li>\n
  2. Boston Children’s Hospital Translational Research Program, mentored Translational Investigator Service Award, awarded August 2024\u00a0<\/span><\/li>\n<\/ol>\n

    [\/et_pb_slide][et_pb_slide heading=”Diamond Blackfan Chair of Neuroscience Research (May 2022)” button_text=”Click Here” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

    Dr. Poduri has been appointed as the inaugural incumbent of the Diamond Blackfan Chair In Neuroscience Research at Boston Children\u2019s<\/p>\n

    [\/et_pb_slide][et_pb_slide heading=”Grass Foundation Young Investigator Award (September 2021)” image=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2020\/01\/Koh_Hyunyong-20626-1-e1579190127658.jpg” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

    Congratulations to Hyunyong (Howard) Koh for winning the 2021 Grass Foundation Young Investigator Award! This honor, granted by the American Epilepsy Society for his abstract “Non-cell Autonomous Hyperexcitability Underlies Focal Epileptogenesis Mediated By Low-Level Brain Somatic Mutations In MTOR\u201d, was selected out of over 1,300 submissions.<\/p>\n

    [\/et_pb_slide][et_pb_slide heading=”International Precision Child Health Partnership (IPCHiP) Genomic Study in Infants with Epilepsy (February 2021)” button_text=”Click Here” button_link=”https:\/\/www.childrenshospital.org\/newsroom\/news-and-events\/2021\/four-leading-childrens-hospitals-announce-ipchip” url_new_window=”on” _builder_version=”4.27.4″ _module_preset=”default” link_option_url=”https:\/\/www.childrenshospital.org\/newsroom\/news-and-events\/2021\/four-leading-childrens-hospitals-announce-ipchip” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

    We are collaborating will three international pediatric hospitals –\u00a0UCL Great Ormond Street Institute for Child Health and Great Ormond Street Hospital (London); the Murdoch Children\u2019s Research Institute with The Royal Children\u2019s Hospital (Melbourne); and The Hospital for Sick Children (Toronto) –\u00a0to launch IPCHiP’s first project: a genomic sequencing study in infants with epilepsy.<\/p>\n

    [\/et_pb_slide][et_pb_slide heading=”Epilepsy Genetics Program Newsletter (May 2020)” button_text=”Click Here” button_link=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2020\/05\/Newsletter_2020.pdf” url_new_window=”on” image=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2020\/05\/Newsletter-front-page-.jpg” _builder_version=”4.27.4″ header_font=”||||||||” link_option_url=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2020\/05\/Newsletter_2020.pdf” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

    Read about the clinical and lab research projects we are actively working on, and all the latest news in our group!<\/p>\n

    [\/et_pb_slide][et_pb_slide heading=”Harvard Club of Boston’s Most Influential Women (February 2020)” button_text=”Click Here” button_link=”https:\/\/www.harvardclub.com\/harvard-club-of-boston-announces-its-2020-bostons-most-influential-women-gala-honorees\/%20″ url_new_window=”on” image=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2020\/02\/Harvard-Club-1.jpg” _builder_version=”4.27.4″ link_option_url=”https:\/\/www.harvardclub.com\/harvard-club-of-boston-announces-its-2020-bostons-most-influential-women-gala-honorees\/ ” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

    Dr. Poduri was selected as one of seven honorees at the Harvard Club of Boston\u2019s Most Influential Women Gala.<\/p>\n

    [\/et_pb_slide][et_pb_slide heading=”Science Magazine Feature on Epilepsy Research (December 2019)” button_text=”Click Here” button_link=”https:\/\/science.sciencemag.org\/content\/366\/6471\/1300″ url_new_window=”on” image=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2020\/02\/Science-Magazine.jpg” _builder_version=”4.27.4″ body_font=”||||||||” link_option_url=”https:\/\/science.sciencemag.org\/content\/366\/6471\/1300″ link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

    Dr. Poduri was interviewed as a part of Science Magazine<\/em>‘s feature on novel approaches to discovering treatments for drug-resistant epilepsy.<\/p>\n

    [\/et_pb_slide][et_pb_slide heading=”The Boston Globe featuring the Poduri Lab’s Research (September 2019)” button_text=”Click Here” button_link=”https:\/\/www.bostonglobe.com\/lifestyle\/health-wellness\/2019\/09\/27\/meet-researchers-working-curb-childhood-cancer-repair-your-acl-stop-epileptic-seizures-and-more\/AMy0K7J9nzfrfvWTtwey1K\/story.html” url_new_window=”on” image=”https:\/\/kirbyneuro.org\/PoduriLab\/wp-content\/uploads\/2019\/11\/Boston-Globe_Ann-Poduri_Sept-2019.jpg” _builder_version=”4.27.4″ header_font=”|600|||||||” link_option_url=”https:\/\/www.bostonglobe.com\/lifestyle\/health-wellness\/2019\/09\/27\/meet-researchers-working-curb-childhood-cancer-repair-your-acl-stop-epileptic-seizures-and-more\/AMy0K7J9nzfrfvWTtwey1K\/story.html” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

    Dr. Poduri’s work with zebrafish to unravel the genetic causes of epilepsy was highlighted in The Boston Globe<\/em>‘s article about the cutting-edge research being performed at Boston Children’s Hospital.<\/p>\n

    [\/et_pb_slide][et_pb_slide heading=”The Wall Street Journal Article on Genetic Tests (May 2019)” button_text=”Click Here” button_link=”https:\/\/www.wsj.com\/articles\/dna-testing-was-meant-to-help-treat-esmes-illness-it-created-turmoil-11558093193″ url_new_window=”on” _builder_version=”4.27.4″ header_font=”|600|||||||” link_option_url=”https:\/\/www.wsj.com\/articles\/dna-testing-was-meant-to-help-treat-esmes-illness-it-created-turmoil-11558093193″ link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

    Dr. Poduri was quoted in The Wall Street Journal<\/em> article, “The Unfulfilled Promise of Genetic Testing”, addressing the challenges of using rapidly-evolving genetic tests for the diagnosis of rare diseases.<\/p>\n

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    Transgenic zebrafish brain with inhibitory and excitatory neurons labelled green and red, respectivelyWelcome to the Poduri Lab!   The Poduri Laboratory was launched in 2013 within the Department of Neurology and F.M. Kirby Neurobiology Center at Boston Children\u2019s Hospital. Our translational Epilepsy Genetics Program encompasses human genetics research in epilepsy in parallel with bench laboratory […]<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\n

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